KS 176

Name: KS 176
Brand: Tocris Bioscience
SKU: 4169

Tocris Bioscience, part of Bio-Techne | Catalog # 4169

COA / SDS

Selective BCRP inhibitor

Key Product Details

Description:	Selective BCRP inhibitor
Chemical Name:	N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	405.4

View Full Technical Details for KS 176

Technical Data
Citations

Biological Activity for KS 176

KS 176 is a selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC₅₀ values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.

Technical Data for KS 176

M. Wt	405.4
Formula	C₂₂H₁₉N₃O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1253452-78-6
PubChem ID	49779726
InChi Key	LTWQQWSXYYXVGA-UHFFFAOYSA-N
Smiles	OCCC1=CC=C(NC(C2=C(NC(C3=CC=C([N+]([O-])=O)C=C3)=O)C=CC=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KS 176

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.54	100

Preparing Stock Solutions for KS 176

The following data is based on the product molecular weight 405.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.33 mL	24.67 mL
5 mM	0.49 mL	2.47 mL	4.93 mL
10 mM	0.25 mL	1.23 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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Reconstitution Calculator

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References for KS 176

References are publications that support the biological activity of the product.

Pick Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem 2010 PMID: 20632361