L-701,324

Name: L-701,324
Brand: Tocris Bioscience
SKU: 0907

Tocris Bioscience, part of Bio-Techne | Catalog # 0907

Citations (9)

COA / SDS

NMDA antagonist; acts at glycine site

Key Product Details

Description:	NMDA antagonist; acts at glycine site
Chemical Name:	7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
Purity:	≥99% (HPLC)
Molecular Weight:	363.8

View Full Technical Details for L-701,324

Technical Data
Citations

Biological Activity for L-701,324

L-701,324 is a an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data for L-701,324

M. Wt	363.8
Formula	C₂₁H₁₄ClNO₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	142326-59-8
PubChem ID	54682505
InChi Key	FLVRDMUHUXVRET-UHFFFAOYSA-N
Smiles	OC1=C(C(=O)NC2=CC(Cl)=CC=C12)C1=CC=CC(OC2=CC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-701,324

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for L-701,324

The following data is based on the product molecular weight 363.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.75 mL	13.74 mL	27.49 mL
5 mM	0.55 mL	2.75 mL	5.50 mL
10 mM	0.27 mL	1.37 mL	2.75 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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References for L-701,324

References are publications that support the biological activity of the product.

Obrenovitch and Zilkha Inhibition of cortical spreading depression by L-701,324, a novel antagonist at the glycine site of the N-MthD.-aspartate receptor complex. Br.J.Pharmacol. 1996 PMID: 8851513
Bristow Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-MthD.-aspartate receptor complex. J.Pharmacol.Exp.Ther. 1996 PMID: 8930150
Kulagowski 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor. J.Med.Chem. 1994 PMID: 8182696
Bristow The atypical neuroleptic profile of the glycine/N-MthD.-aspartate receptor antagonist, L-701,324 in rodents. J.Pharmacol.Exp.Ther. 1996 PMID: 8627534