L-798,106

Name: L-798,106
Brand: Tocris Bioscience
SKU: 3342
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3342

Citations (34)

COA / SDS

Potent and highly selective EP3 antagonist

Key Product Details

Description:	Potent and highly selective EP₃ antagonist
Chemical Name:	N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide
Purity:	≥99% (HPLC)
Molecular Weight:	536.44

View Full Technical Details for L-798,106

Technical Data
Citations

Biological Activity for L-798,106

L-798,106 is a potent and highly selective prostanoid EP₃ receptor antagonist (K_i values are 0.3, 916, > 5000 and > 5000 nM at EP₃, EP₄, EP₁ and EP₂ respectively). Attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo.

Compound Libraries for L-798,106

L-798,106 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-798,106

M. Wt	536.44
Formula	C₂₇H₂₂BrNO₄S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	244101-02-8
PubChem ID	15551229
InChi Key	ODTKFNUPVBULRJ-NTCAYCPXSA-N
Smiles	O=C(NS(C4=C(OC)C=CC(Br)=C4)(=O)=O)/C=C/C1=CC=CC=C1CC3=CC2=CC=CC=C2C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-798,106

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	53.64	100

Preparing Stock Solutions for L-798,106

The following data is based on the product molecular weight 536.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.32 mL	18.64 mL
5 mM	0.37 mL	1.86 mL	3.73 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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References for L-798,106

References are publications that support the biological activity of the product.

Clarke E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP₃-subtype. Br.J.Pharmacol. 2004 PMID: 14744812
Bassil Activation of prostaglandin EP receptors by lubipro. in rat and human stomach and colon. Br.J.Pharmacol. 2008 PMID: 18332851
Juteau Structure-activity relationships of cinnamic acylsulfonamide analogues on human EP₃ prostanoid receptor. Bioorg.Med.Chem. 2001 PMID: 11504634