L Moses dihydrochloride

Name: L Moses dihydrochloride
Brand: Tocris Bioscience
SKU: 6251

Tocris Bioscience, part of Bio-Techne | Catalog # 6251

Citations (2)

COA / SDS

High affinity and selective PCAF bromodomain inhibitor

Key Product Details

Description:	High affinity and selective PCAF bromodomain inhibitor
Chemical Name:	(1S, 2S)-N¹,N¹-Dimethyl-N²-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	433.38

View Full Technical Details for L Moses dihydrochloride

Technical Data
Citations

Biological Activity for L Moses dihydrochloride

L Moses dihydrochloride is a high affinity and selective cell-permeable p300/CBP-associated factor (PCAF) inhibitor (K_i = 47 nM), which exhibits no significant activity against a panel of 48 other bromodomains except GCN5 (K_d = 600 nM). L Moses exhibits >4500-fold selectivity for PCAF over BRD4. The compound inhibits Tunicamycin (Cat. No. 3516) -induced neuronal cell death by reversing the transcriptional changes associated with Tunicamycin treatment. L Moses exhibits metabolic stability in mouse and human liver microsomes and no observable cytotoxicity in peripheral blood mononuclear cells (PBMC).

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the L-Moses probe summary on the SGC website.

Compound Libraries for L Moses dihydrochloride

L Moses dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of L-Moses is reviewed on the chemical probes website.

Technical Data for L Moses dihydrochloride

M. Wt	433.38
Formula	C₂₁H₂₄N₆.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
PubChem ID	131698638
InChi Key	MSFPLTWUFWOKBX-IFXJQAMLSA-N
Smiles	C[C@@H]([C@H](C1=CC=CC=C1)N(C)C)NC2=NN3C(C)=NN=C3C4=CC=CC=C24

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L Moses dihydrochloride

	Solvent	Max Conc. mM
Solubility
	water	100
	DMSO	100

Preparing Stock Solutions for L Moses dihydrochloride

The following data is based on the product molecular weight 433.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.54 mL	23.07 mL
5 mM	0.46 mL	2.31 mL	4.61 mL
10 mM	0.23 mL	1.15 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for L Moses dihydrochloride

References are publications that support the biological activity of the product.

Pavlou CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death. Sci Rep 2023 PMID: 36894612
Moustakim Discovery of a PCAF bromodomain chemical probe. Angew.Chem.Int.Ed. 2017 PMID: 27966810