Licarbazepine

Name: Licarbazepine
Brand: Tocris Bioscience
SKU: 3865

Tocris Bioscience, part of Bio-Techne | Catalog # 3865

(1)

Citations (2)

COA / SDS

Active metabolite of oxcarbazepine (Cat. No. 3864)

Key Product Details

Chemical Name:	10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide
Purity:	≥98%
Molecular Weight:	254.28 kDa

View Full Technical Details for Licarbazepine

Technical Data
Citations / Reviews (1)

Biological Activity for Licarbazepine

Licarbazepine is an active metabolite of oxcarbazepine (Cat. No. 3864). Produces dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs). Displays anticonvulsant activity; exhibits minor potentiation of GABA_A receptor currents.

Technical Data for Licarbazepine

M. Wt	254.28 kDa
Formula	C₁₅H₁₄N₂O₂
Storage	Store at RT
Purity	≥98%
CAS Number	29331-92-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Licarbazepine

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Licarbazepine

References are publications that support the biological activity of the product.

Zheng et al. Oxcarbazepine, not its active metabolite, potentiates GABA_A activation and aggravates absence seizures. Epilepsia, 2009;50:83 PMID: 18717705
Calabresi et al. Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. I. Modulation of corticostriatal synaptic transmission. Epilepsia, 1995;36:990 PMID: 7555963
Benes et al. Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J.Med.Chem., 1999;42:2582 PMID: 10411478