Linifanib

Name: Linifanib
Brand: Tocris Bioscience
SKU: 7743

Tocris Bioscience, part of Bio-Techne | Catalog # 7743

Citations (1)

COA / SDS

Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R

Key Product Details

Chemical Name:	N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Purity:	≥98%

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Technical Data
Citations

Biological Activity for Linifanib

Linifanib is a potent receptor tyrosine kinase (RTK) inhibitor. It inhibits PDGFRβ, KDR, FLT3, CSF-1R (IC₅₀ values are 2, 4, 4 and 7 nM, respectively). Linifanib inhibits angiogenesis in vascularized micro-organs and potently inhibits VEGF-stimulated endothelial cell proliferation (IC₅₀= 0.2 nM). Linifanib also promotes the generation and reprogramming of iPSCs from somatic cells.

Technical Data for Linifanib

Formula	C₂₁H₁₈FN₅O
Storage	Store at -20°C
Purity	≥98%
CAS Number	796967-16-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Linifanib

Solubility

Soluble Soluble to 20 mM in ethanol and to 100 mM in DMSO

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Product Documents for Linifanib

COA

Certificate of Analysis

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