PDGF R beta: Small Molecules and Peptides
PDGF R beta is a transmembrane receptor tyrosine kinase (RTK) that primarily binds to the PDGF-BB isoform of the growth factor. Ligand binding induces receptor homodimerization or heterodimerization with PDGF R alpha followed by autophosphorylation and signal transduction. PDGF receptor signaling is attenuated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. The expression of the alpha and beta receptors is independently regulated in various cell types. A soluble splice variant of PDGF R beta binds PDGF with high affinity and functions as a potent PDGF antagonist.
Products:
14 results for "PDGF R beta Small Molecules and Peptides" in Products
14 results for "PDGF R beta Small Molecules and Peptides" in Products
PDGF R beta: Small Molecules and Peptides
PDGF R beta is a transmembrane receptor tyrosine kinase (RTK) that primarily binds to the PDGF-BB isoform of the growth factor. Ligand binding induces receptor homodimerization or heterodimerization with PDGF R alpha followed by autophosphorylation and signal transduction. PDGF receptor signaling is attenuated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. The expression of the alpha and beta receptors is independently regulated in various cell types. A soluble splice variant of PDGF R beta binds PDGF with high affinity and functions as a potent PDGF antagonist.
Products:
Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R
| Chemical Name: | N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea |
| Purity: | ≥98% (HPLC) |
Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT
| Chemical Name: | 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent VEGFR, PDGFR and FGFR inhibitor
| Chemical Name: | Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene]-2-oxoindoline-6-carboxylate |
| Purity: | ≥98% |
c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation
| Chemical Name: | N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea |
| Purity: | ≥97% (HPLC) |
Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor
| Chemical Name: | 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide |
| Purity: | ≥98% (HPLC) |
Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1
| Chemical Name: | 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride |
| Purity: | ≥99% (HPLC) |
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit
| Alternate Names: | Gleevec,CGP 57148B |
| Chemical Name: | 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate |
| Purity: | ≥98% (HPLC) |
Potent and selective PDGFR inhibitor
| Chemical Name: | 1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine |
| Purity: | ≥98% (HPLC) |
Potent and selective PDGFR family inhibitor
| Chemical Name: | N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide |
| Purity: | ≥99% (HPLC) |
Potent inhibitor of VEGFR, PDGFR and FGFR
| Chemical Name: | 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline |
| Purity: | ≥98% (HPLC) |
Potent VEGFR, PDGFRβ and KIT inhibitor
| Alternate Names: | SU 11248 |
| Chemical Name: | N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioate salt |
| Purity: | ≥99% (HPLC) |
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
| Chemical Name: | 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine |
| Purity: | ≥98% (HPLC) |
Potent and selective PDGFRβ inhibitor
| Chemical Name: | 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid |
| Purity: | ≥98% (HPLC) |
Potent PDGFRα and PDGFRβ inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases
| Chemical Name: | N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine |
| Purity: | ≥98% (HPLC) |
