LL-K9-3

Name: LL-K9-3
Brand: Tocris Bioscience
SKU: 7813

Tocris Bioscience, part of Bio-Techne | Catalog # 7813

COA / SDS

Selective HyT-based degrader of the CDK9-cyclin T1 complex

Key Product Details

Description:	Selective HyT-based degrader of the CDK9-cyclin T1 complex
Chemical Name:	N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-1-[[2-[[2-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]acetyl]amino]ethyl]sulfonyl]-4-piperidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	683.94

View Full Technical Details for LL-K9-3

Technical Data
Citations

Biological Activity for LL-K9-3

LL-K9-3 is a selective hydrophobic tagging technologies (HyT)-based Degrader of the CDK9-cyclin T1 complex (DC₅₀ values are 589 and 662 nM for cyclin T1 and CDK9, respectively). It comprises a CDK9 inhibitor, SNS 032 (Cat. No. 4075), joined by a glycol linker to hydrophobic tag. LL-K9-3 exhibits no degradation of other CDKs (CDK1, 2, 4, 5, 6, and 7). In 22RV1 cells. LL-K9-3 reduces expression of androgen receptor (AR) and cMyc by inducing selective and synchronous degradation of CDK9 and cyclin T1.

Technical Data for LL-K9-3

M. Wt	683.94
Formula	C₃₁H₄₉N₅O₆S₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2809353-52-2
PubChem ID	164946948
InChi Key	NPRIWHDFWDSJRZ-YFNKSVMNSA-N
Smiles	O=S(CCNC(CO[C@H]1[C@@H](CC[C@H](C1)C)C(C)C)=O)(N2CCC(CC2)C(NC3=NC=C(SCC4=NC=C(C(C)(C)C)O4)S3)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LL-K9-3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	68.39	100
	ethanol	3.42	5

Preparing Stock Solutions for LL-K9-3

The following data is based on the product molecular weight 683.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.46 mL	7.31 mL	14.62 mL
5 mM	0.29 mL	1.46 mL	2.92 mL
10 mM	0.15 mL	0.73 mL	1.46 mL
50 mM	0.03 mL	0.15 mL	0.29 mL

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References for LL-K9-3

References are publications that support the biological activity of the product.

Li Discovery of small-molecule degraders of the CDK9-cyclin T1 complex for targeting transcriptional addiction in prostate cancer. J.Med.Chem. 2022 PMID: 35925880