SNS 032

Name: SNS 032
Brand: Tocris Bioscience
SKU: 4075

Tocris Bioscience, part of Bio-Techne | Catalog # 4075

Citations (8)

COA / SDS

Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9

Key Product Details

Chemical Name:	N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide
Purity:	≥99%
Molecular Weight:	380.53 kDa

View Full Technical Details for SNS 032

Technical Data
Citations

Biological Activity for SNS 032

SNS 032 is a cyclin dependent kinase (cdk) inhibitor (reported IC₅₀ values are 0.004 - 0.048, 0.0045 - 0.05, 0.062 - 0.29, 0.2-0.48, 0.4 and 0.45 μM for cdk9, cdk2, cdk7, cdk1, cdk5 and cdk4, respectively). Displays no activity against 190 additional kinases (IC₅₀ >1 μM). Arrests the cell cycle at G₂/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.

Technical Data for SNS 032

M. Wt	380.53 kDa
Formula	C₁₇H₂₄N₄O₂S₂
Storage	Store at -20°C
Purity	≥99%
CAS Number	345627-80-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SNS 032

Solubility

Soluble Soluble to 50 mM in DMSO

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References for SNS 032

References are publications that support the biological activity of the product.

Jorda et al. How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem., 2018;61:9105 PMID: 30234987
Ali et al. SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. Neoplasia, 2007;9:370 PMID: 17534442
Conroy et al. SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemother.Pharmacol., 2009;64:723 PMID: 19169685
Chen et al. Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line. Cancer Res., 2010;70:6587 PMID: 20663900
Misra et al. N-(Cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent J.Med.Chem., 2004;47:1719 PMID: 15027863