LY 2955303

Name: LY 2955303
Brand: Tocris Bioscience
SKU: 5984

Tocris Bioscience, part of Bio-Techne | Catalog # 5984

Citations (2)

COA / SDS

High affinity and selective RARγ antagonist

Key Product Details

Description:	High affinity and selective RARγ antagonist
Chemical Name:	4-[5-[3,5-Bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	578.74

View Full Technical Details for LY 2955303

Technical Data
Citations

Biological Activity for LY 2955303

LY 2955303 is a high affinity and selective RARγ antagonist (K_i values are 1.1 nM, >1.7 μM and >2.9 μM for RARγ, RARα and RARβ respectively). Displays analgesic efficacy in a mouse model of osteoarthritis-like joint pain.

Compound Libraries for LY 2955303

LY 2955303 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LY 2955303

M. Wt	578.74
Formula	C₃₆H₄₂N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1433497-19-8
PubChem ID	71552369
InChi Key	YVXYHNKIOFSFMZ-UHFFFAOYSA-N
Smiles	CN1CCN(C(C2=CC=C(N3N=C(C4=CC=C(C(O)=O)C=C4)C=C3C5=CC(C(C)(C)C)=CC(C(C)(C)C)=C5)C=C2)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 2955303

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.57	20

Preparing Stock Solutions for LY 2955303

The following data is based on the product molecular weight 578.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.64 mL	43.20 mL	86.39 mL
1 mM	1.73 mL	8.64 mL	17.28 mL
2 mM	0.86 mL	4.32 mL	8.64 mL
10 mM	0.17 mL	0.86 mL	1.73 mL

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References for LY 2955303

References are publications that support the biological activity of the product.

Hughes Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg.Med.Chem.Letts. 2016 PMID: 27261179