LY 367385

Name: LY 367385
Brand: Tocris Bioscience
SKU: 1237
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1237

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Citations (257)

COA / SDS

Selective mGlu1a antagonist

Key Product Details

Description:	Selective mGlu_1a antagonist
Chemical Name:	(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid
Purity:	≥99% (HPLC)
Molecular Weight:	209.2

View Full Technical Details for LY 367385

Technical Data
Citations / Reviews (1)

Biological Activity for LY 367385

LY 367385 is a selective mGlu_1a receptor antagonist, with an IC₅₀ value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis vs. > 100 μM for mGlu_5a, and negligible action on group II and III receptors.

Licensing Information

Sold with the permission of Eli Lilly and Company

Technical Data for LY 367385

M. Wt	209.2
Formula	C₁₀H₁₁NO₄
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	198419-91-9
PubChem ID	5311261
InChi Key	SGIKDIUCJAUSRD-QMMMGPOBSA-N
Smiles	N[C@H](C(O)=O)C1=C(C)C=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 367385

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH	10.46	50 with gentle warming with sonication

Preparing Stock Solutions for LY 367385

The following data is based on the product molecular weight 209.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	9.56 mL	47.80 mL	95.60 mL
2.5 mM	1.91 mL	9.56 mL	19.12 mL
5 mM	0.96 mL	4.78 mL	9.56 mL
25 mM	0.19 mL	0.96 mL	1.91 mL

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Reconstitution Calculator

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References for LY 367385

References are publications that support the biological activity of the product.

Clark (+)-2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett.
Chapman Anticonvulsant actions of LY 367385 ((+)-methyl-4-carboxyphenylglycine), and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). Eur.J.Pharmacol. 1999 PMID: 10096765
Salt and Turner Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine. Neuroscience 1998 PMID: 9639261
Bruno Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept Neuropharmacology 1999 PMID: 10218860