Maraviroc

Name: Maraviroc
Brand: Tocris Bioscience
SKU: 3756

Tocris Bioscience, part of Bio-Techne | Catalog # 3756

(1)

Citations (25)

COA / SDS

Selective CCR5 antagonist

Key Product Details

Chemical Name:	4,4-Difluoro-N-{(1S)-3-[3-(3-isopropyl- 5-methyl-4H-1,2,4-triazol-4-yl)- 8-azabicyclo[3.2.1]oct-8-yl]-1- phenylpropyl}cyclohexanecarboxamide
Purity:	≥99%
Molecular Weight:	513.67 kDa

View Full Technical Details for Maraviroc

Technical Data
Citations / Reviews (1)

Biological Activity for Maraviroc

Maraviroc is a selective CCR5 antagonist; displays potent anti-HIV-1 activity. Prevents the interaction of HIV-1 gp120 and CCR5 (IC₅₀ = 6.4 nM), inhibiting HIV-1 entry. Exhibits antinociceptive effects in a rat model of neuropathic pain. Also inhibits CCL3 (MIP-1α) binding to CCR5. Orally bioavailable.

Technical Data for Maraviroc

M. Wt	513.67 kDa
Formula	C₂₉H₄₁F₂N₅O
Storage	Store at +4°C
Purity	≥99%
CAS Number	376348-65-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Maraviroc

Solubility

Soluble Soluble to 75 mM in DMSO and to 100 mM in ethanol

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References for Maraviroc

References are publications that support the biological activity of the product.

M Jo, JH Kim, G Song, M Seo, E Mi Hwang, K Suk Astrocytic orosomucoid-2 modulates microglial activation and neuroinflammation J. Neurosci, 2017;0(0):. 2017 PMID: 28193696
Corbisier J, Gales C, Huszagh A, Parmentier M, Springael J Biased signaling at chemokine receptors. J Biol Chem, 2015;290(15):9542-54. 2015 PMID: 25614627
Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. Nat Commun, 2014;5(0):4715. 2014 PMID: 25178650
CH Lee, HH Zhang, SP Singh, L Koo, J Kabat, H Tsang, TP Singh, JM Farber C/EBP? drives interactions between human MAIT cells and endothelial cells that are important for extravasation Elife, 2018;7(0):. 2018 PMID: 29469805
Lourenco S, Teixeira V, Kalber T, Jose R, Floto R, Janes S Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol, 2015;194(7):3463-74. 2015 PMID: 25712213
K Jin, NB Pandey, AS Popel Simultaneous blockade of IL-6 and CCL5 signaling for synergistic inhibition of triple-negative breast cancer growth and metastasis Breast Cancer Res., 2018;20(1):54. 2018 PMID: 29898755
Dorr et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob.Agents Chemother., 2005;49:4721 PMID: 16251317
Garcia-Perez et al. New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection. J.Biol.Chem., 2011;286:4978 PMID: 21118814
Piotrowska et al. Maraviroc reduces neuropathic pain through polarization of microglia and astroglia - Evidence from in vivo and in vitro studies. Neuropharmacology, 2016;S0028-3908:30164 PMID: 27117708
Kuritzkes et al. Fresh from the pipeline - mara. Nat.Rev.Drug Discov., 2008;7:15