Mirin

Name: Mirin
Brand: Tocris Bioscience
SKU: 3190

Tocris Bioscience, part of Bio-Techne | Catalog # 3190

Citations (27)

COA / SDS

MRN-ATM pathway inhibitor

Key Product Details

Description:	MRN-ATM pathway inhibitor
Chemical Name:	Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
Purity:	≥99% (HPLC)
Molecular Weight:	220.25

View Full Technical Details for Mirin

Technical Data
Citations

Biological Activity for Mirin

Mirin is a Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC₅₀ = 12 μM) and induces G₂ cell cycle arrest. Also blocks homology-directed repair in vitro.

Compound Libraries for Mirin

Mirin is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Mirin

M. Wt	220.25
Formula	C₁₀H₈N₂O₂S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1198097-97-0
PubChem ID	1206243
InChi Key	YBHQCJILTOVLHD-YVMONPNESA-N
Smiles	OC(C=C1)=CC=C1/C=C2/C(NC(S2)=N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mirin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.02	100

Preparing Stock Solutions for Mirin

The following data is based on the product molecular weight 220.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.54 mL	22.70 mL	45.40 mL
5 mM	0.91 mL	4.54 mL	9.08 mL
10 mM	0.45 mL	2.27 mL	4.54 mL
50 mM	0.09 mL	0.45 mL	0.91 mL

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References for Mirin

References are publications that support the biological activity of the product.

Stivers Small molecule versus DNA repair mechanisms. Nat.Chem.Biol. 2008 PMID: 18202674
Garner Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 2009 PMID: 19219009
Dupre A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 2008 PMID: 18176557