ML 339

Tocris Bioscience, part of Bio-Techne | Catalog # 5943

COA / SDS

Potent and selective hCXCR6 antagonist

Key Product Details

Description:	Potent and selective hCXCR6 antagonist
Chemical Name:	N-[(1R,3S,5S)-9-(2-((2-Chlorophenyl)amino)-2-exoethyl)-9-azabicyclo[3.3.1]nonan-3-yl)-3,4,5-trimethoxybenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	502

View Full Technical Details for ML 339

Technical Data
Citations

Biological Activity for ML 339

ML 339 is a potent and selective hCXCR6 antagonist (IC₅₀ = 140 nM); 100-fold less active at the murine CXCR6 receptor (IC₅₀ = 18 μM). Exhibits selectivity over CXCR5, CXCR4, CCR6 and APJ receptors (IC₅₀ >79 μM).

Compound Libraries for ML 339

ML 339 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for ML 339

M. Wt	502
Formula	C₂₆H₃₂ClN₃O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	2080300-49-6
PubChem ID	60202254
InChi Key	SSPYAPRDKNCABY-UHFFFAOYSA-N
Smiles	O=C(NC1=C(Cl)C=CC=C1)CN2[C@H]3CCC[C@@H]2C[C@](NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)([H])C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 339

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	50.2	100
	ethanol	10.04	20

Preparing Stock Solutions for ML 339

The following data is based on the product molecular weight 502.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.96 mL	19.92 mL
5 mM	0.40 mL	1.99 mL	3.98 mL
10 mM	0.20 mL	1.00 mL	1.99 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for ML 339

References are publications that support the biological activity of the product.

Hershberger Probing the CXCR6/CXCL16 Axis: targeting prevention of prostate cancer metastasis. Probe Reports from the NIH Molecular Libraries Program 2012 PMID: 24049849