ML 385

Name: ML 385
Brand: Tocris Bioscience
SKU: 6243
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6243

Citations (7)

COA / SDS

Nrf2 inhibitor; phenotypically lethal

Key Product Details

Description:	Nrf2 inhibitor; phenotypically lethal
Chemical Name:	N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	511.59

View Full Technical Details for ML 385

Technical Data
Citations

Biological Activity for ML 385

ML 385 is an Nrf2 inhibitor. Blocks Nrf2 downstream target gene expression. Enhances cytotoxic effects of doxorubicin (Cat. No. 2252) or Taxol (Cat. No. 1097) in non-small cell lung cancer (NSCLC). Demonstrates selectivity for NSCLC cells with KEAP1 mutations.

Compound Libraries for ML 385

ML 385 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 385

M. Wt	511.59
Formula	C₂₉H₂₅N₃O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	846557-71-9
PubChem ID	1383822
InChi Key	LINHYWKZVCNAMQ-UHFFFAOYSA-N
Smiles	CC1=C(C2=CC=C3N(C(C4=C(C=CC=C4)C)=O)CCC3=C2)N=C(S1)NC(CC5=CC=C6OCOC6=C5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 385

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.58	50

Preparing Stock Solutions for ML 385

The following data is based on the product molecular weight 511.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.91 mL	19.55 mL	39.09 mL
2.5 mM	0.78 mL	3.91 mL	7.82 mL
5 mM	0.39 mL	1.95 mL	3.91 mL
25 mM	0.08 mL	0.39 mL	0.78 mL

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References for ML 385

References are publications that support the biological activity of the product.

Singh Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors. ACS Chem.Biol. 2016 PMID: 27552339