MPEP hydrochloride

Name: MPEP hydrochloride
Brand: Tocris Bioscience
SKU: 1212
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1212

(3)

Citations (49)

COA / SDS

Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors

Key Product Details

Description:	Potent mGlu₅ antagonist; also positive allosteric modulator of mGlu₄ receptors
Chemical Name:	2-Methyl-6-(phenylethynyl)pyridine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	229.71

View Full Technical Details for MPEP hydrochloride

Technical Data
Citations / Reviews (3)

Biological Activity for MPEP hydrochloride

MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu₅ receptor subtype (IC₅₀ = 36 nM) and a positive allosteric modulator at mGlu₄ receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.

Compound Libraries for MPEP hydrochloride

MPEP hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MPEP hydrochloride

M. Wt	229.71
Formula	C₁₄H₁₁N.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	219911-35-0
PubChem ID	9794588
InChi Key	PKDHDJBNEKXCBI-UHFFFAOYSA-N
Smiles	Cl.CC1=CC=CC(=N1)C#CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MPEP hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	1.15	5 with gentle warming
	DMSO	22.97	100

Preparing Stock Solutions for MPEP hydrochloride

The following data is based on the product molecular weight 229.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.35 mL	21.77 mL	43.53 mL
5 mM	0.87 mL	4.35 mL	8.71 mL
10 mM	0.44 mL	2.18 mL	4.35 mL
50 mM	0.09 mL	0.44 mL	0.87 mL

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Reconstitution Calculator

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References for MPEP hydrochloride

References are publications that support the biological activity of the product.

Bowes Anti-hyperalgesic effects of the novel metabotropic glutamate receptor 5 antagonist, methylphenylethynylpyridine, in rat models of inflammatory pain. Br.J.Pharmacol.
Mathiesen Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br.J.Pharmacol. 2003 PMID: 12684257
Salt Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br.J.Pharmacol. 1999 PMID: 10455248
Gasparini 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology 1999 PMID: 10530811