MTEP hydrochloride

Name: MTEP hydrochloride
Brand: Tocris Bioscience
SKU: 2921

Tocris Bioscience, part of Bio-Techne | Catalog # 2921

Citations (25)

COA / SDS

Potent and selective mGlu5 antagonist

Key Product Details

Description:	Potent and selective mGlu₅ antagonist
Chemical Name:	3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	236.72

View Full Technical Details for MTEP hydrochloride

Technical Data
Citations

Biological Activity for MTEP hydrochloride

MTEP hydrochloride is a potent, selective and non-competitive mGlu₅ antagonist (IC₅₀ = 5 nM in Ca²⁺-flux assay; K_i= 16 nM). Displays anxiolytic activity in vivo and is orally active.

Licensing Information

Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)

Compound Libraries for MTEP hydrochloride

MTEP hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MTEP hydrochloride

M. Wt	236.72
Formula	C₁₁H₈N₂S.HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1186195-60-7
PubChem ID	45073467
InChi Key	YCIOJDKGCWAHLR-UHFFFAOYSA-N
Smiles	CC1=NC(C#CC2=CN=CC=C2)=CS1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MTEP hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	23.67	100
	DMSO	23.67	100

Preparing Stock Solutions for MTEP hydrochloride

The following data is based on the product molecular weight 236.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.22 mL	21.12 mL	42.24 mL
5 mM	0.84 mL	4.22 mL	8.45 mL
10 mM	0.42 mL	2.11 mL	4.22 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

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Reconstitution Calculator

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References for MTEP hydrochloride

References are publications that support the biological activity of the product.

Brodkin Reduced stress-induced hyperthermia in mGluR5 knockout mice. Eur.J.Neurosci. 2002 PMID: 12473093
Cosford 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J.Med.Chem. 2003 PMID: 12519057
Roppe 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity. Bioorg.Med.Chem.Lett. 2004 PMID: 15225713
Klodzinska Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA_A signaling. Neuropharmacology 2004 PMID: 15275823
Bradbury Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice. J.Pharmacol.Exp.Ther. 2005 PMID: 15590770