NBI 27914 hydrochloride

Name: NBI 27914 hydrochloride
Brand: Tocris Bioscience
SKU: 1591

Tocris Bioscience, part of Bio-Techne | Catalog # 1591

Citations (4)

COA / SDS

Selective non-peptide CRF1 antagonist

Key Product Details

Description:	Selective non-peptide CRF₁ antagonist
Chemical Name:	5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	470.66

View Full Technical Details for NBI 27914 hydrochloride

Technical Data
Citations

Biological Activity for NBI 27914 hydrochloride

NBI 27914 hydrochloride is a selective, non-peptide corticotropin-releasing factor₁ (CRF₁) receptor antagonist (K_i = 1.7 nM); has no activity at CRF₂ receptors. Blocks behavioral seizures in vivo.

Compound Libraries for NBI 27914 hydrochloride

NBI 27914 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NBI 27914 hydrochloride

M. Wt	470.66
Formula	C₁₈H₂₀Cl₄N₄.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1215766-76-9
PubChem ID	45073446
InChi Key	CPMGENCTAWBLNW-UHFFFAOYSA-N
Smiles	Cl.CCCN(CC1CC1)C1=C(Cl)C(NC2=C(Cl)C=C(Cl)C=C2Cl)=NC(C)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NBI 27914 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	43.42	100
	DMSO	43.42	100

Preparing Stock Solutions for NBI 27914 hydrochloride

The following data is based on the product molecular weight 470.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.62 mL	21.25 mL
5 mM	0.42 mL	2.12 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for NBI 27914 hydrochloride

References are publications that support the biological activity of the product.

Chen Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor₁ receptor antagonists. J.Med.Chem. 1996 PMID: 8893829
McCarthy Recent advances with the CRF₁ receptor: design of small molecule inhibitors, receptor subtypes and clinical indications. Curr.Pharm.Des. 1999 PMID: 10213797
Baram The CRF₁ receptor mediates the excitatory actions of cortico. releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res. 1997 PMID: 9372207