CRF1 Receptor Antagonists: Small Molecules and Peptides
CRHR1, also known as CHR-R1 and Corticotropin Releasing Factor Receptor 1, CRF 1, is a member of the Class B G protein-coupled receptor family that mediates the action of hypothalamic and peripheral CRH. It is the key regulator of the stress response in the hypothalamic-pituitary adrenal axis and an important functional mediator of the endocrine, cardiovascular, gastrointestinal, and immune systems. The other major endogenous ligand for CRHR1 is Urocortin 1.
7 results for "CRF1 Receptor Antagonists Small Molecules and Peptides" in Products
7 results for "CRF1 Receptor Antagonists Small Molecules and Peptides" in Products
CRF1 Receptor Antagonists: Small Molecules and Peptides
CRHR1, also known as CHR-R1 and Corticotropin Releasing Factor Receptor 1, CRF 1, is a member of the Class B G protein-coupled receptor family that mediates the action of hypothalamic and peripheral CRH. It is the key regulator of the stress response in the hypothalamic-pituitary adrenal axis and an important functional mediator of the endocrine, cardiovascular, gastrointestinal, and immune systems. The other major endogenous ligand for CRHR1 is Urocortin 1.
High affinity CRF1 antagonist; orally bioavailable
| Chemical Name: | 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective CRF1 antagonist; anxiolytic
| Chemical Name: | 8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine |
| Purity: | ≥98% (HPLC) |
Potent and selective CRF1 antagonist; binds at an allosteric site
| Chemical Name: | N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride |
| Purity: | ≥99% (HPLC) |
CRF1 antagonist
| Chemical Name: | N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride |
| Purity: | ≥99% (HPLC) |
Selective non-peptide CRF1 antagonist
| Chemical Name: | 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride |
| Purity: | ≥99% (HPLC) |
Potent and selective CRF1 antagonist
| Chemical Name: | (7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective, non-peptide CRF1 antagonist
| Chemical Name: | N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride |
| Purity: | ≥99% (HPLC) |
