NF 157

Tocris Bioscience, part of Bio-Techne | Catalog # 2450

COA / SDS

Selective P2Y11 and P2X1 antagonist

Key Product Details

Chemical Name:	8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Purity:	≥90%

View Full Technical Details for NF 157

Technical Data
Citations

Biological Activity for NF 157

NF 157 is a purinergic receptor antagonist that potently inhibits P2Y₁₁ receptor activity (IC₅₀ = 463 nM). Displays selectivity for P2Y₁₁ and P2X₁ receptors over P2Y₁, P2Y₂, P2X₂, P2X₃, P2X₄ and P2X₇ receptors. Inhibits NAD⁺-induced activation of human granulocytes.

This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content and the maximum solubility threshold to use in dilution calculations.

Technical Data for NF 157

Formula	C₄₉H₂₈F₂N₆Na₆O₂₃S₆
Storage	Desiccate at RT
Purity	≥90%
CAS Number	104869-26-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NF 157

Solubility

Soluble Soluble to 5 mg/ml in water and to 10 mg/ml in DMSO

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References for NF 157

References are publications that support the biological activity of the product.

Fritsche G, Nairz M, Libby S, Fang F, Weiss G Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression. J Leukoc Biol, 2012;92(2):353-9. 2012 PMID: 22706314
Ullmann et al. Synthesis and structure-activity relationships of suramin-derived P2Y₁₁ receptor antagonists with nanomolar potency. J.Med.Chem., 2005;48:7040 PMID: 16250663
Moreschi et al. Extracellular NAD⁺ is an agonist of the human P2Y₁₁ purinergic receptor in human granulocytes. J.Biol.Chem., 2006;281:31419 PMID: 16926152

NF 157

Tocris Bioscience, part of Bio-Techne | Catalog # 2450

Key Product Details

Biological Activity for NF 157

Technical Data for NF 157

Solubility for NF 157

Dilution Calculator

Reconstitution Calculator

References for NF 157

Product Documents for NF 157

COA

Certificate of Analysis

SDS

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