NF 157

Tocris Bioscience, part of Bio-Techne | Catalog # 2450

COA / SDS

Selective P2Y11 and P2X1 antagonist

Key Product Details

Description:	Selective P2Y₁₁ and P2X₁ antagonist
Chemical Name:	8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Purity:	≥90% (HPLC)
Molecular Weight:	1437.08

View Full Technical Details for NF 157

Technical Data
Citations

Biological Activity for NF 157

NF 157 is a purinergic receptor antagonist that potently inhibits P2Y₁₁ receptor activity (IC₅₀ = 463 nM). Displays selectivity for P2Y₁₁ and P2X₁ receptors over P2Y₁, P2Y₂, P2X₂, P2X₃, P2X₄ and P2X₇ receptors. Inhibits NAD⁺-induced activation of human granulocytes.

This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content and the maximum solubility threshold to use in dilution calculations.

Technical Data for NF 157

M. Wt	1437.08
Formula	C₄₉H₂₈F₂N₆Na₆O₂₃S₆
Storage	Desiccate at RT
Purity	≥90% (HPLC)
CAS Number	104869-26-3
PubChem ID	71433548
InChi Key	QJFCMJZVZFAWGF-UHFFFAOYSA-H
Smiles	[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]OOSC1=C2C(NC(=O)C3=CC(NC(=O)C4=CC(NC(=O)NC5=CC(=CC=C5)C(=O)NC5=CC(=CC=C5F)C(=O)NC5=CC=C(C6=CC(=CC(=C56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C4)=C(F)C=C3)=CC=C(C2=CC(=C1)S([O-])(=O)=O)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NF 157

	Solvent	Max Conc. mg/mL
Solubility
	water	5
	DMSO	10

Preparing Stock Solutions for NF 157

The following data is based on the product molecular weight 1437.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.07 mM	9.94 mL	49.70 mL	99.41 mL
0.35 mM	1.99 mL	9.94 mL	19.88 mL
0.7 mM	0.99 mL	4.97 mL	9.94 mL
3.5 mM	0.20 mL	0.99 mL	1.99 mL

Molarity Calculator

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Reconstitution Calculator

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References for NF 157

References are publications that support the biological activity of the product.

Moreschi Extracellular NAD⁺ is an agonist of the human P2Y₁₁ purinergic receptor in human granulocytes. J.Biol.Chem. 2006 PMID: 16926152
Ullmann Synthesis and structure-activity relationships of suramin-derived P2Y₁₁ receptor antagonists with nanomolar potency. J.Med.Chem. 2005 PMID: 16250663