Nigericin sodium salt

Name: Nigericin sodium salt
Brand: Tocris Bioscience
SKU: 4312

Tocris Bioscience, part of Bio-Techne | Catalog # 4312

Citations (33)

COA / SDS

Selective K+ ionophore

Key Product Details

Chemical Name:	(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt
Molecular Weight:	746.94 kDa

View Full Technical Details for Nigericin sodium salt

Technical Data
Citations

Biological Activity for Nigericin sodium salt

Nigericin sodium salt is a potassium ionophore; it exchanges K⁺ for H⁺ across biological membranes in a similar manner to Valinomycin (Cat. No. 3373). Nigericin stimulates mitochondrial ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb²⁺ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.

Technical Data for Nigericin sodium salt

M. Wt	746.94 kDa
Formula	C₄₀H₆₇NaO₁₁
Storage	Store at -20°C
CAS Number	28643-80-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nigericin sodium salt

Solubility

Soluble Soluble to 100 mM in ethanol

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References for Nigericin sodium salt

References are publications that support the biological activity of the product.

H Ahn, E Jeon, JC Kim, SG Kang, SI Yoon, HJ Ko, PH Kim, GS Lee Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production Sci Rep, 2017;7(1):1314. 2017 PMID: 28465544
MG Khalafalla, LT Woods, JM Camden, AA Khan, KH Limesand, MJ Petris, L Erb, GA Weisman P2X7 receptor antagonism prevents IL-1? release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy J. Biol. Chem., 2017;0(0):. 2017 PMID: 28798231
Hamidinia et al. The ionophore Nigericin transports Pb²⁺ with high activity and selectivity: A comparison to Monensin and Ionomycin. Biochemistry., 2004;43:15956 PMID: 15595852
Eytan et al. Energy-linked transhydrogenase: Effects of Valinomycin and Nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted transhydrogenase-ATPase vesicles. J.Biol.Chem., 1990;22:12949