Nigericin sodium salt

Name: Nigericin sodium salt
Brand: Tocris Bioscience
SKU: 4312

Tocris Bioscience, part of Bio-Techne | Catalog # 4312

Citations (33)

COA / SDS

Selective K+ ionophore

Key Product Details

Description:	Selective K⁺ ionophore
Chemical Name:	(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt
Molecular Weight:	746.94

View Full Technical Details for Nigericin sodium salt

Technical Data
Citations

Biological Activity for Nigericin sodium salt

Nigericin sodium salt is a potassium ionophore; it exchanges K⁺ for H⁺ across biological membranes in a similar manner to Valinomycin (Cat. No. 3373). Nigericin stimulates mitochondrial ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb²⁺ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.

Technical Data for Nigericin sodium salt

M. Wt	746.94
Formula	C₄₀H₆₇NaO₁₁
Storage	Store at -20°C
CAS Number	28643-80-3
PubChem ID	16760591
InChi Key	MOYOTUKECQMGHE-PDEFJWSRSA-M
Smiles	[Na+].[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]1(C)CC[C@@]([H])(O1)[C@]1(C)C[C@@H](C)[C@]2(O1)O[C@]([H])(C[C@@]1([H])CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@@H](OC)[C@H]2C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nigericin sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	ethanol	74.69	100

Preparing Stock Solutions for Nigericin sodium salt

The following data is based on the product molecular weight 746.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.34 mL	6.69 mL	13.39 mL
5 mM	0.27 mL	1.34 mL	2.68 mL
10 mM	0.13 mL	0.67 mL	1.34 mL
50 mM	0.03 mL	0.13 mL	0.27 mL

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References for Nigericin sodium salt

References are publications that support the biological activity of the product.

Eytan Energy-linked transhydrogenase: Effects of Valinomycin and Nigericin on the ATP-driven transhydrogenase reaction catalyzed by reconstituted transhydrogenase-ATPase vesicles. J.Biol.Chem.
Hamidinia The ionophore Nigericin transports Pb²⁺ with high activity and selectivity: A comparison to Monensin and Ionomycin. Biochemistry. 2004 PMID: 15595852