Norketamine hydrochloride

Name: Norketamine hydrochloride
Brand: Tocris Bioscience
SKU: 1970

Tocris Bioscience, part of Bio-Techne | Catalog # 1970

Citations (13)

COA / SDS

Potent non-competitive NMDA antagonist; antinociceptive

Key Product Details

Chemical Name:	2-Amino-2-(2-chlorophenyl)cyclohexanone hydrochloride
Purity:	≥99%

View Full Technical Details for Norketamine hydrochloride

Technical Data
Citations

Biological Activity for Norketamine hydrochloride

Norketamine hydrochloride is a major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (K_i = 3.6 μM for displacement of [³H]-MK 801 in rat brain). Antinociceptive and anesthetic in vivo.

R-enantiomer and S-enantiomer also available.

Technical Data for Norketamine hydrochloride

Formula	C₁₂H₁₄ClNO.HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	79499-59-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Norketamine hydrochloride

Solubility

Soluble Soluble to 100 mM in water

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References for Norketamine hydrochloride

References are publications that support the biological activity of the product.

Leung et al. Comparative pharmacology in the rat of KA and its two principal metabolites, norKA and (Z)-6-hydroxynorKA. J.Med.Chem., 1986;29:2396 PMID: 3783598
Ebert et al. NorKA, the main metabolite of KA, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord. Eur.J.Pharmacol., 1997;333:99 PMID: 9311667
Shimoyama et al. Oral KA is antinociceptive in the rat formalin test: role of the metabolite, norKA. Pain, 1999;81:85 PMID: 10353496

Norketamine hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1970

Key Product Details

Biological Activity for Norketamine hydrochloride

Technical Data for Norketamine hydrochloride

Solubility for Norketamine hydrochloride

Dilution Calculator

Reconstitution Calculator

References for Norketamine hydrochloride

Product Documents for Norketamine hydrochloride

COA

Certificate of Analysis

SDS

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