NU 9056

Name: NU 9056
Brand: Tocris Bioscience
SKU: 4903
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4903

Citations (35)

COA / SDS

Inhibitor of KAT5 (Tip60)

Key Product Details

Description:	Inhibitor of KAT5 (Tip60)
Chemical Name:	5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole
Molecular Weight:	232.37

View Full Technical Details for NU 9056

Technical Data
Citations

Biological Activity for NU 9056

NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC₅₀ values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.

Technical Data for NU 9056

M. Wt	232.37
Formula	C₆H₄N₂S₄
Storage	Store at -20°C
CAS Number	1450644-28-6
PubChem ID	72201043
InChi Key	MLRAMCAHIWHWRM-UHFFFAOYSA-N
Smiles	C1(SSC2=CC=NS2)=CC=NS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NU 9056

Solubility

Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

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References for NU 9056

References are publications that support the biological activity of the product.

Coffey Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One 2012 PMID: 23056207