Histone Acetyltransferase Inhibitors: Small Molecules and Peptides
Histone Acetyltransferases (HATs) are also known as Lysine Aceyltransferases or KATs. These are domains found in a diverse range of enzymes, and they are responsible for catalyzing the acetylation of lysine residues. This post-translational modification involves the transfer of an acetyl group from acetyl CoA to form ε-N-acetyl lysine.
11 results for "Histone Acetyltransferase Inhibitors Small Molecules and Peptides" in Products
11 results for "Histone Acetyltransferase Inhibitors Small Molecules and Peptides" in Products
Histone Acetyltransferase Inhibitors: Small Molecules and Peptides
Histone Acetyltransferases (HATs) are also known as Lysine Aceyltransferases or KATs. These are domains found in a diverse range of enzymes, and they are responsible for catalyzing the acetylation of lysine residues. This post-translational modification involves the transfer of an acetyl group from acetyl CoA to form ε-N-acetyl lysine.
Inhibitor of KAT5 (Tip60)
| Chemical Name: | 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole |
Potent and selective p300/CBP inhibitor; orally bioavailable
| Chemical Name: | (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide |
| Purity: | ≥98% (HPLC) |
Lysine acetyltransferase HBO1 (KAT7) inhibitor
| Chemical Name: | N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide |
| Purity: | ≥98% (HPLC) |
Potent p300/CBP inhibitor
| Chemical Name: | (1'S,3'R)-3'-Fluoro-N-[(4-fluorophenyl)methyl]-2',3'-dihydro-5'-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1'-[1H]indene]-1-acetamide |
| Purity: | ≥98% |
Potent and selective KAT6A and KAT6B inhibitor
| Chemical Name: | N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide |
| Purity: | ≥98% |
Noncompetitive PCAF/p300 inhibitor
| Chemical Name: | 2-Hydroxy-6-pentadecylbenzoic acid |
| Purity: | ≥97% (HPLC) |
Reversible and non-competitive CBP/p300 inhibitor
| Chemical Name: | 5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione |
| Purity: | ≥98% (HPLC) |
High affinity KAT6A (MOZ) competitive inhibitor
| Chemical Name: | 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide |
| Purity: | ≥98% |
Steroid receptor coactivator 3 (SRC-3) inhibitor
| Chemical Name: | 1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective EP300 Degrader (PROTAC®)
| Chemical Name: | 12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3'-(2-((4-fluorobenzyl)((S)-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-5-yl)dodecanamide |
| Purity: | ≥98% (HPLC) |
Negative control for iP300w (Cat. No. 7270)
| Chemical Name: | (1'R,3'S)-3'-Fluoro-N-[(4-fluorophenyl)methyl]-2',3'-dihydro-5'-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1'-[1H]indene]-1-acetamide |
| Purity: | ≥98% |
