ONO AE3 208

Name: ONO AE3 208
Brand: Tocris Bioscience
SKU: 3565
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3565

(1)

Citations (11)

COA / SDS

High affinity and selective EP4 antagonist

Key Product Details

Chemical Name:	4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoic acid
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for ONO AE3 208

ONO AE3 208 is a high affinity and selective EP₄ receptor antagonist (K_i values are 1.3, 30, 790 and 2400 nM for EP₄, EP₃, FP and TP receptors respectively). Displays no affinity for EP₁, EP₂, DP or IP receptors (K_i >10 μM). Inhibits PGE₂-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE₂ inhibition of natural killer T cell activation. Suppresses recovery from experimentally-induced colitis and stimulates CD4⁺ T cell proliferation in C57BL/6 mice. Also reduces metastasis of mammary tumor cells in a murine model of breast cancer. Orally active.

Technical Data for ONO AE3 208

Formula	C₂₄H₂₁FN₂O₃
Storage	Store at -20°C
Purity	≥98%
CAS Number	402473-54-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ONO AE3 208

Solubility

Soluble Soluble to 100 mM in DMSO

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References for ONO AE3 208

References are publications that support the biological activity of the product.

Deng et al. Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells. J.Immunol., 2013;190:3579 PMID: 23467936
Ma et al. Prostaglandin E receptor EP₄ antagonism inhibits breast cancer metastasis. Cancer Res., 2006;66:2923 PMID: 16540639
Dey et al. Prostaglandin E₂ couples through EP₄ prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines. Br.J.Pharmacol, 2009;3:475 PMID: 19175605
Kabashima et al. The prostaglandin receptor EP₄ suppresses colitis, mucosal damage and CD⁴ cell activation in the gut. J.Clin.Invest., 2002;109:883 PMID: 11927615

ONO AE3 208

Tocris Bioscience, part of Bio-Techne | Catalog # 3565

Key Product Details

Biological Activity for ONO AE3 208

Technical Data for ONO AE3 208

Solubility for ONO AE3 208

Dilution Calculator

Reconstitution Calculator

References for ONO AE3 208

Product Documents for ONO AE3 208

COA

Certificate of Analysis

SDS

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