Oxaliplatin

Name: Oxaliplatin
Brand: Tocris Bioscience
SKU: 2623

Tocris Bioscience, part of Bio-Techne | Catalog # 2623

(2)

Citations (60)

COA / SDS

DNA cross-linking antitumor agent

Key Product Details

Chemical Name:	Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
Purity:	≥99%
Molecular Weight:	397.29 kDa

View Full Technical Details for Oxaliplatin

Technical Data
Citations / Reviews (2)

Biological Activity for Oxaliplatin

Oxaliplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (Cat. No. 2251) and shows antitumor activity in cell lines with acquired cisplatin resistance.

Technical Data for Oxaliplatin

M. Wt	397.29 kDa
Formula	C₈H₁₄N₂O₄Pt
Storage	Store at +4°C
Purity	≥99%
CAS Number	61825-94-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Oxaliplatin

Solubility

Soluble Soluble to 5 mM in water with gentle warming

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References for Oxaliplatin

References are publications that support the biological activity of the product.

Culy et al. Oxaliplatin. A review of its pharmacological properties and clinical efficacy in metastatic colorectal cancer and its potential in other malignancies. Drugs, 2000;60:895 PMID: 11085200
Mani et al. Oxaliplatin: a review of evolving concepts. Cancer Invest., 2002;20:246 PMID: 11901545
Raymond et al. Cellular and molecular pharmacology of oxalip. Mol.Cancer Ther., 2002;1:227 PMID: 12467217