PD 158780

Name: PD 158780
Brand: Tocris Bioscience
SKU: 2615
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2615

(1)

Citations (10)

COA / SDS

Potent ErbB receptor family inhibitor

Key Product Details

Chemical Name:	N⁴-(3-Bromophenyl)-N⁶-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine
Purity:	≥99%
Molecular Weight:	330.18 kDa

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Technical Data
Citations / Reviews (1)

Biological Activity for PD 158780

PD 158780 is a potent inhibitor of ErbB receptor family tyrosine kinases (IC₅₀ values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G₁ cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.

Technical Data for PD 158780

M. Wt	330.18 kDa
Formula	C₁₄H₁₂BrN₅
Storage	Store at -20°C
Purity	≥99%
CAS Number	171179-06-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 158780

Solubility

Soluble Soluble to 100 mM in DMSO and to 25 mM in ethanol

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References for PD 158780

References are publications that support the biological activity of the product.

Fry et al. Biochemical and antiproliferative properties of 4-[ar(alk)ylmino]pyridopyrimidines, a new chemical class of potent and specific epidermal growth factor receptor tyrosine kinase inhibitor. Biochem.Pharmacol., 1997;54:877 PMID: 9354588
Sun et al. Growth inhibition of nasopharyngeal carcinoma cells by EGF receptor tyrosine kinase inhibitors. Anticancer Res., 1999;19:919 PMID: 10368634
Gonzales et al. G1 cell cycle arrest due to inhibition of erbB family receptor tyrosine kinases does not require the retinoblastoma protein. Exp.Cell Res., 2005;303:56 PMID: 15572027