PF 06551600 malonate

Name: PF 06551600 malonate
Brand: Tocris Bioscience
SKU: 6506

Tocris Bioscience, part of Bio-Techne | Catalog # 6506

(1)

Citations (2)

COA / SDS

Potent and selective JAK3 inhibitor

Key Product Details

Chemical Name:	1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate
Purity:	≥98%

View Full Technical Details for PF 06551600 malonate

Technical Data
Citations / Reviews (1)

Biological Activity for PF 06551600 malonate

PF 06551600 malonate is a potent and selective JAK3 inhibitor (IC₅₀ = 33.1 μM). Exhibits no significant activity against a panel of other kinases including JAK1, JAK2 and TYK2. Inhibits phosphorylation of STAT5, induced by IL-2, IL-4, IL-7 and IL-15. Suppresses Th1 and Th17 T-cell differentiation and function in vitro. Reduces paw swelling in a rat model of arthritis and reduces disease severity in a rat EAE model.

Technical Data for PF 06551600 malonate

Formula	C₁₅H₁₉N₅O.C₃H₄O₄
Storage	Store at +4°C
Purity	≥98%
CAS Number	2140301-97-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 06551600 malonate

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for PF 06551600 malonate

References are publications that support the biological activity of the product.

Thorarensen et al. Design of a Janus Kinase 3 (JAK3) specific inhibitor 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) allowing for the interrogation of JAK3 signaling in humans. J.Med.Chem., 2017;60:1971 PMID: 28139931
Telliez et al. Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition. ACS Chem.Biol., 2016;11:3442 PMID: 27791347

PF 06551600 malonate

Tocris Bioscience, part of Bio-Techne | Catalog # 6506

Key Product Details

Biological Activity for PF 06551600 malonate

Technical Data for PF 06551600 malonate

Solubility for PF 06551600 malonate

Dilution Calculator

Reconstitution Calculator

References for PF 06551600 malonate

Product Documents for PF 06551600 malonate

COA

Certificate of Analysis

SDS

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