PP 3

Name: PP 3
Brand: Tocris Bioscience
SKU: 2794

Tocris Bioscience, part of Bio-Techne | Catalog # 2794

Citations (22)

COA / SDS

Negative control for PP 2 (Cat. No. 1407)

Key Product Details

Description:	Negative control for PP 2 (Cat. No. 1407)
Chemical Name:	1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity:	≥98% (HPLC)
Molecular Weight:	211.22

View Full Technical Details for PP 3

Technical Data
Citations

Biological Activity for PP 3

PP 3 is a negative control for the Src kinase inhibitor, PP 2. Inhibits EGFR kinase (IC₅₀ = 2.7 μM).

Active Analog also available.

Compound Libraries for PP 3

PP 3 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PP 3

M. Wt	211.22
Formula	C₁₁H₉N₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	5334-30-5
PubChem ID	4879
InChi Key	KKDPIZPUTYIBFX-UHFFFAOYSA-N
Smiles	NC1=NC=NC2=C1C=NN2C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PP 3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	21.12	100
	ethanol	5.28	25

Preparing Stock Solutions for PP 3

The following data is based on the product molecular weight 211.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.73 mL	23.67 mL	47.34 mL
5 mM	0.95 mL	4.73 mL	9.47 mL
10 mM	0.47 mL	2.37 mL	4.73 mL
50 mM	0.09 mL	0.47 mL	0.95 mL

Molarity Calculator

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Reconstitution Calculator

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References for PP 3

References are publications that support the biological activity of the product.

Hou PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci.Letts. 2007 PMID: 17556100
Traxler Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J.Med.Chem. 1997 PMID: 9357527