Pyrimethamine

Name: Pyrimethamine
Brand: Tocris Bioscience
SKU: 3918

Tocris Bioscience, part of Bio-Techne | Catalog # 3918

Citations (2)

COA / SDS

Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor

Key Product Details

Chemical Name:	5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
Purity:	≥99%
Molecular Weight:	248.71 kDa

View Full Technical Details for Pyrimethamine

Technical Data
Citations

Biological Activity for Pyrimethamine

Pyrimethamine is a potent inhibitor of multidrug and toxin extrusion (MATE) transporters (K_i values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. Decreases proliferation of human autosomal dominant polycystic kidney disease cells.

Technical Data for Pyrimethamine

M. Wt	248.71 kDa
Formula	C₁₂H₁₃ClN₄
Storage	Store at RT
Purity	≥99%
CAS Number	58-14-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pyrimethamine

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in ethanol

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References for Pyrimethamine

References are publications that support the biological activity of the product.

Takakura et al. Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum.Mol.Genet., 2011;20:4143 PMID: 21821671
Ito et al. Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimeth. J.Pharmacol.Exp.Ther., 2010;333:341 PMID: 20065018
Zimmerman et al. Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimeth. and pyrimeth. Am.J.Clin.Nutr., 1987;46:518 PMID: 3630970

Product Documents for Pyrimethamine

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Pyrimethamine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov