QNZ 46

Name: QNZ 46
Brand: Tocris Bioscience
SKU: 4801

Tocris Bioscience, part of Bio-Techne | Catalog # 4801

Citations (10)

COA / SDS

Non-competitive and GluN2C/GluN2D-selective NMDA antagonist

Key Product Details

Description:	Non-competitive and GluN2C/GluN2D-selective NMDA antagonist
Chemical Name:	4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	443.41

View Full Technical Details for QNZ 46

Technical Data
Citations

Biological Activity for QNZ 46

QNZ 46 is a GluN2C/GluN2D-selective NMDA receptor non-competitive antagonist (IC₅₀ values are 3, 6, 229, and >300, >300 μM for GluN2D, GluN2C, GluN2A, GluN2B, and GluR1, respectively). Requires binding of glutamate to the GluN2 subunit.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Compound Libraries for QNZ 46

QNZ 46 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for QNZ 46

M. Wt	443.41
Formula	C₂₄H₁₇N₃O₆
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1237744-13-6
PubChem ID	46861929
InChi Key	GNLVJIICVWDSNI-LFYBBSHMSA-N
Smiles	O=C2C1=CC(OC)=CC=C1N=C(/C=C/C4=CC([N+]([O-])=O)=CC=C4)N2C3=CC=C(C(O)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for QNZ 46

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.43	10 with gentle warming

Preparing Stock Solutions for QNZ 46

The following data is based on the product molecular weight 443.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.55 mL	112.76 mL	225.52 mL
0.5 mM	4.51 mL	22.55 mL	45.10 mL
1 mM	2.26 mL	11.28 mL	22.55 mL
5 mM	0.45 mL	2.26 mL	4.51 mL

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References for QNZ 46

References are publications that support the biological activity of the product.

Hansen and Traynelis Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J.Neurosci. 2011 PMID: 21389220
Mosley Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-MthD.-aspartate receptor antagonists. J.Med.Chem. 2010 PMID: 20684595