(R)-CE3F4

Name: (R)-CE3F4
Brand: Tocris Bioscience
SKU: 5969

Tocris Bioscience, part of Bio-Techne | Catalog # 5969

Citations (3)

COA / SDS

Epac inhibitor; R-enantiomer of CE3F4 (Cat. No. 4793)

Key Product Details

Description:	Epac inhibitor; R-enantiomer of CE3F4 (Cat. No. 4793)
Chemical Name:	(2R)-5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
Purity:	≥98% (HPLC)
Molecular Weight:	351.01

View Full Technical Details for (R)-CE3F4

Technical Data
Citations

Biological Activity for (R)-CE3F4

(R)-CE3F4 is an Epac inhibitor (IC₅₀ values are 4.2 and 44 μM for Epac1 and Epac2(B), respectively). Blocks activation of Epac by cAMP. This is the R-enantiomer of CE3F4 (Cat.No.4793).

Licensing Information

Sold for research use only under license from Inserm, Université Toulouse III - Paul Sabatier, Université Paris-Sud and Université d′Orléans.

Technical Data for (R)-CE3F4

M. Wt	351.01
Formula	C₁₁H₁₀Br₂FNO
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1593478-56-8
PubChem ID	73669655
InChi Key	ZZLQPWXVZCPUGC-ZCFIWIBFSA-N
Smiles	BrC1=C(F)C(Br)=C(CC[C@@H](C)N2C=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-CE3F4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.1	100
	ethanol	17.55	50

Preparing Stock Solutions for (R)-CE3F4

The following data is based on the product molecular weight 351.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.24 mL	28.49 mL
5 mM	0.57 mL	2.85 mL	5.70 mL
10 mM	0.28 mL	1.42 mL	2.85 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for (R)-CE3F4

References are publications that support the biological activity of the product.

Boulton Mechanism of selective enzyme inhibition through uncompetitive regulation of an allosteric agonist. J.Am.Chem.Soc. 2018 PMID: 30016089
Courilleau The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem.Biophys.Res.Commun. 2013 PMID: 24099776