Roscovitine

Name: Roscovitine
Brand: Tocris Bioscience
SKU: 1332

Tocris Bioscience, part of Bio-Techne | Catalog # 1332

Citations (40)

COA / SDS

Cdk inhibitor

Key Product Details

Alternative Names:	CYC 202,Seliciclib
Chemical Name:	(2R)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
Purity:	≥98% (HPLC)
Molecular Weight:	354.45

View Full Technical Details for Roscovitine

Technical Data
Citations

Biological Activity for Roscovitine

Roscovitine is a cyclin-dependent kinase (cdk) inhibitor. Displays sub-micromolar inhibition of cdk1, cdk2, cdk5, cdk7 and cdk9 (reported IC₅₀ values range from 0.16 - 0.28 μM for cdk5 to 0.8 μM for cdk7). Selective for cdks over a wide range of related kinases including ERK1 and ERK2. Arrests L1210 cells in G1 phase. Inhibits phosphorylation of vimentin in vivo. Antimitotic.

Compound Libraries for Roscovitine

Roscovitine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Roscovitine

M. Wt	354.45
Formula	C₁₉H₂₆N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	186692-46-6
PubChem ID	160355
InChi Key	BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Smiles	OC[C@@H](CC)NC1=NC(N(C(C)C)C=N2)=C2C(NCC3=CC=CC=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Roscovitine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.44	100
	ethanol	35.44	100

Preparing Stock Solutions for Roscovitine

The following data is based on the product molecular weight 354.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.82 mL	14.11 mL	28.21 mL
5 mM	0.56 mL	2.82 mL	5.64 mL
10 mM	0.28 mL	1.41 mL	2.82 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for Roscovitine

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Meijer Chemical inhibitors of cyclin-dependent kinases. Trends Cell.Biol. 1996 PMID: 15157522
Meijer Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur.J.Biochem. 1997 PMID: 9030781
De Azevedo Inhibition of cyclin-dependent kinases by purine analogues. Eur.J.Biochem. 1997 PMID: 9030780