RS 102895 hydrochloride

Name: RS 102895 hydrochloride
Brand: Tocris Bioscience
SKU: 2089

Tocris Bioscience, part of Bio-Techne | Catalog # 2089

Citations (8)

COA / SDS

CCR2b chemokine receptor antagonist

Key Product Details

Description:	CCR2b chemokine receptor antagonist
Chemical Name:	1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	426.86

View Full Technical Details for RS 102895 hydrochloride

Technical Data
Citations

Biological Activity for RS 102895 hydrochloride

RS 102895 hydrochloride is a CCR2-selective chemokine receptor antagonist (IC₅₀ values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC₅₀ values of 32 nM and 1.7 μM respectively. Also inhibits α_1A, α_1D and 5-HT_1A receptors.

Compound Libraries for RS 102895 hydrochloride

RS 102895 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for RS 102895 hydrochloride

M. Wt	426.86
Formula	C₂₁H₂₁F₃N₂O₂.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1173022-16-6
PubChem ID	16759153
InChi Key	KRRISOFSWVKYBF-UHFFFAOYSA-N
Smiles	Cl.FC(F)(F)C1=CC=C(CCN2CCC3(CC2)OC(=O)NC2=CC=CC=C32)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RS 102895 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.01	75

Preparing Stock Solutions for RS 102895 hydrochloride

The following data is based on the product molecular weight 426.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.12 mL	15.62 mL	31.24 mL
3.75 mM	0.62 mL	3.12 mL	6.25 mL
7.5 mM	0.31 mL	1.56 mL	3.12 mL
37.5 mM	0.06 mL	0.31 mL	0.62 mL

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References for RS 102895 hydrochloride

References are publications that support the biological activity of the product.

Mirzadegan Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists. J.Biol.Chem. 2000 PMID: 10770925
Clark Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'piperidin]-2(1H)-ones. J.Med.Chem. 1983 PMID: 6842505