Rucaparib camsylate

Name: Rucaparib camsylate
Brand: Tocris Bioscience
SKU: 6230

Tocris Bioscience, part of Bio-Techne | Catalog # 6230

Citations (1)

COA / SDS

PARP inhibitor

Key Product Details

Description:	PARP inhibitor
Alternative Names:	CO-338
Chemical Name:	8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2,ef][2]benzazepin-6-one (1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid
Purity:	≥98% (HPLC)
Molecular Weight:	555.66

View Full Technical Details for Rucaparib camsylate

Technical Data
Citations

Biological Activity for Rucaparib camsylate

Rucaparib camsylate is a PARP inhibitor. Chemosensitizes colorectal cancer cells to Temozolomide (Cat. No. 2706) and Topotecan (Cat. No. 4562) in vitro and in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Rucaparib camsylate

Rucaparib camsylate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rucaparib camsylate

M. Wt	555.66
Formula	C₁₉H₁₈FN₃O.C₁₀H₁₆O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1859053-21-6
PubChem ID	53356947
InChi Key	INBJJAFXHQQSRW-FHIDHQGESA-N
Smiles	CNCC1=CC=C(C2=C3CCNC(C4=C3C(N2)=CC(F)=C4)=O)C=C1.O=S(C[C@@]5(C6(C)C)CC[C@@H]6CC5=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rucaparib camsylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	55.57	100

Preparing Stock Solutions for Rucaparib camsylate

The following data is based on the product molecular weight 555.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.80 mL	9.00 mL	18.00 mL
5 mM	0.36 mL	1.80 mL	3.60 mL
10 mM	0.18 mL	0.90 mL	1.80 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for Rucaparib camsylate

References are publications that support the biological activity of the product.

Thomas Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol.Cancer Ther. 2007 PMID: 17363489