Ruxolitinib phosphate

Name: Ruxolitinib phosphate
Brand: Tocris Bioscience
SKU: 7048

Tocris Bioscience, part of Bio-Techne | Catalog # 7048

Citations (1)

COA / SDS

Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor

Key Product Details

Description:	Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor
Chemical Name:	(3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphate
Purity:	≥98% (HPLC)
Molecular Weight:	404.37

View Full Technical Details for Ruxolitinib phosphate

Technical Data
Citations

Biological Activity for Ruxolitinib phosphate

Ruxolitinib phosphate is a phosphate salt of Ruxolitinib (Cat. No. 7064). Potent and selective JAK1/JAK2 inhibitor; orally bioavailable.

Compound Libraries for Ruxolitinib phosphate

Ruxolitinib phosphate is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Ruxolitinib phosphate

M. Wt	404.37
Formula	C₁₇H₁₈N₆.H₃O₄P
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1092939-17-7
PubChem ID	25127112
InChi Key	JFMWPOCYMYGEDM-XFULWGLBSA-N
Smiles	OP(O)(O)=O.N#CC[C@@H](N1C=C(C2=C3C=CNC3=NC=N2)C=N1)C4CCCC4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ruxolitinib phosphate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.44	100
	ethanol	4.04	10

Preparing Stock Solutions for Ruxolitinib phosphate

The following data is based on the product molecular weight 404.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.36 mL	24.73 mL
5 mM	0.49 mL	2.47 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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Reconstitution Calculator

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References for Ruxolitinib phosphate

References are publications that support the biological activity of the product.

Quintás-Cardama Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 2010 PMID: 20130243
Lin Enantioselective synthesis of Janus kinase inhibitor INCB018424 via an organocatalytic aza-Michael reaction. Org.Lett. 2019 PMID: 19385672