S 18886

Name: S 18886
Brand: Tocris Bioscience
SKU: 5568

Tocris Bioscience, part of Bio-Techne | Catalog # 5568

Citations (2)

COA / SDS

Potent thromboxane A2 (TP) antagonist

Key Product Details

Description:	Potent thromboxane A₂ (TP) antagonist
Alternative Names:	terutroban
Chemical Name:	(6R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	407.91

View Full Technical Details for S 18886

Technical Data
Citations

Biological Activity for S 18886

S 18886 is a potent thromboxane A₂ (TP) inhibitor (IC₅₀ = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro. Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.

Compound Libraries for S 18886

S 18886 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for S 18886

M. Wt	407.91
Formula	C₂₀H₂₂ClNO₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	165538-40-9
PubChem ID	9938840
InChi Key	HWEOXFSBSQIWSY-MRXNPFEDSA-N
Smiles	CC1=CC=C(C[C@H](NS(C2=CC=C(Cl)C=C2)(=O)=O)CC3)C3=C1CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for S 18886

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.79	100
	ethanol	8.16	20 with gentle warming

Preparing Stock Solutions for S 18886

The following data is based on the product molecular weight 407.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.26 mL	24.52 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
10 mM	0.25 mL	1.23 mL	2.45 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for S 18886

References are publications that support the biological activity of the product.

Wang Potent, long-acting cyclopentane-1,3-Dione thromboxane (A₂)-receptor antagonists. ACS Med.Chem.Lett. 2014 PMID: 25221659
Cimetière Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists. Bioorg.Med.Chem.Lett. 1998 PMID: 9871769