SA-15-P

Name: SA-15-P
Brand: Tocris Bioscience
SKU: 8050

Tocris Bioscience, part of Bio-Techne | Catalog # 8050

COA / SDS

Dual inhibitor of LAG3 interaction with both MHCII and FGL1

Key Product Details

Description:	Dual inhibitor of LAG3 interaction with both MHCII and FGL1
Chemical Name:	N-[4-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethoxy]phenyl]-2-furancarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	428.49

View Full Technical Details for SA-15-P

Technical Data
Citations

Biological Activity for SA-15-P

SA-15-P is a dual inhibitor of the interaction of lymphocyte activation gene 3 (LAG3) with both the major histocompatibility complex class II (MHCII) and fibrinogen-like protein 1 (FGL1) (IC₅₀ values from TR-FRET assay are 4.2 μM and 6.5 μM respectively).

Technical Data for SA-15-P

M. Wt	428.49
Formula	C₂₆H₂₄N₂O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	852846-00-5
PubChem ID	4786555
InChi Key	IYGLJCOGIQDUAE-UHFFFAOYSA-N
Smiles	O=C(C1=CC=CO1)NC2=CC=C(C=C2)OCC(C3=C(C)N(CC4=CC=CC=C4)C(C)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SA-15-P

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.85	100

Preparing Stock Solutions for SA-15-P

The following data is based on the product molecular weight 428.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.67 mL	23.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL
10 mM	0.23 mL	1.17 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for SA-15-P

References are publications that support the biological activity of the product.

Abdel-Rahman Discovery of first-in-class small molecule inhibitors of lymphocyte activation gene 3 (LAG-3). ACS Med.Chem.Lett. 2023 PMID: 37197466