LAG-3 Products
LAG-3 (Lymphocyte activation gene-3; CD223) is a transmembrane protein that binds to MHC class II molecules and negatively regulates T cell receptor signaling. It is expressed on activated T cells, NK cells, and plasmacytoid dendritic cells (pDC). LAG-3 limits the expansion of activated T cells and pDC in response to select stimuli. Proteolytic shedding of LAG-3 enables normal T cell activation by removing the negative regulation. Binding of a homodimerized soluble LAG-3/Ig fusion protein to MHC class II molecules induces maturation of immature DC as well as secretion of pro-inflammatory cytokines by cytotoxic CD8+ T cells and NK cells.
607 results for "LAG-3" in Products
607 results for "LAG-3" in Products
LAG-3 Products
LAG-3 (Lymphocyte activation gene-3; CD223) is a transmembrane protein that binds to MHC class II molecules and negatively regulates T cell receptor signaling. It is expressed on activated T cells, NK cells, and plasmacytoid dendritic cells (pDC). LAG-3 limits the expansion of activated T cells and pDC in response to select stimuli. Proteolytic shedding of LAG-3 enables normal T cell activation by removing the negative regulation. Binding of a homodimerized soluble LAG-3/Ig fusion protein to MHC class II molecules induces maturation of immature DC as well as secretion of pro-inflammatory cytokines by cytotoxic CD8+ T cells and NK cells.
Build your own multi-plex biomarker immunoassay panel for Ella™. Highly precise and reproducible. Choose from more than 250 fully validated target analytes.
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #CL14773 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow |
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, CyTOF-reported |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
Analyzed by SEC-MALS
| Source: | CHO |
| Accession #: | P18627 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | P18627 |
| Applications: | BA |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #BLR027F |
| Applications: | IHC, WB, ICC/IF, Flow, IP, +1 More |
![Western Blot: LAG-3 Antibody (BLR027F) [NBP2-76402]](https://resources.bio-techne.com/images/products/LAG-3-Antibody-BLR027F-Western-Blot-NBP2-76402-img0007.jpg "Western Blot: LAG-3 Antibody (BLR027F) [NBP2-76402]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | WB, Flow, CyTOF-reported |
Dual inhibitor of LAG3 interaction with both MHCII and FGL1
| Chemical Name: | N-[4-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethoxy]phenyl]-2-furancarboxamide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
![LAG-3 Antibody (874501) [mFluor Violet 610 SE]](https://resources.bio-techne.com/images/products/fab23193mfv610_mouse-lag-3-mab-874501-mfluor-violet-610-se-flow-cytometry-912024143342..jpg "Detection of LAG-3 in PBMCs treated with 5 ug/mL PHA for 5 days cells by Flow Cytometry.")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, MA |
![Immunohistochemistry-Paraffin: LAG-3 Antibody [NBP1-85781]](https://resources.bio-techne.com/images/products/LAG-3-Antibody-Immunohistochemistry-Paraffin-NBP1-85781-img0007.jpg "Immunohistochemistry-Paraffin: LAG-3 Antibody [NBP1-85781]")
Control for use with Human LAG-3 Simple Plex Cartridge Kit
| Applications: | Ctrl, Simple Plex |
Simple Plex Human LAG-3 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #1009611 |
| Applications: | WB, Flow, CyTOF-ready |
Recombinant Monoclonal Antibody.
| Reactivity: | Cynomolgus Monkey |
| Details: | Rabbit IgG Monoclonal Clone #2561B |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #874512 |
| Applications: | Flow, IHC, CyTOF-ready |
| Source: | NS0 |
| Accession #: | Q61790 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #874528 |
| Applications: | Flow, IHC, CyTOF-ready |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #BLR028F |
| Applications: | IHC, WB, ICC/IF, IP |
![Western Blot: LAG-3 Antibody (BLR028F) [NBP2-76403]](https://resources.bio-techne.com/images/products/LAG-3-Antibody-BLR028F-Western-Blot-NBP2-76403-img0003.jpg "Western Blot: LAG-3 Antibody (BLR028F) [NBP2-76403]")
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #631501 |
| Applications: | Flow, CyTOF-ready |
