LAG-3 Products
LAG-3 (Lymphocyte activation gene-3; CD223) is a transmembrane protein that binds to MHC class II molecules and negatively regulates T cell receptor signaling. It is expressed on activated T cells, NK cells, and plasmacytoid dendritic cells (pDC). LAG-3 limits the expansion of activated T cells and pDC in response to select stimuli. Proteolytic shedding of LAG-3 enables normal T cell activation by removing the negative regulation. Binding of a homodimerized soluble LAG-3/Ig fusion protein to MHC class II molecules induces maturation of immature DC as well as secretion of pro-inflammatory cytokines by cytotoxic CD8+ T cells and NK cells.
608 results for "LAG-3" in Products
608 results for "LAG-3" in Products
LAG-3 Products
LAG-3 (Lymphocyte activation gene-3; CD223) is a transmembrane protein that binds to MHC class II molecules and negatively regulates T cell receptor signaling. It is expressed on activated T cells, NK cells, and plasmacytoid dendritic cells (pDC). LAG-3 limits the expansion of activated T cells and pDC in response to select stimuli. Proteolytic shedding of LAG-3 enables normal T cell activation by removing the negative regulation. Binding of a homodimerized soluble LAG-3/Ig fusion protein to MHC class II molecules induces maturation of immature DC as well as secretion of pro-inflammatory cytokines by cytotoxic CD8+ T cells and NK cells.
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
| Applications: | Simple Plex |
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow |
Analyzed by SEC-MALS
| Source: | CHO |
| Accession #: | P18627 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #17B4 |
| Applications: | IHC, WB, ICC/IF, Flow, IP, +1 More |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, CyTOF-reported |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | WB, Flow, CyTOF-reported |
| Source: | NS0 |
| Accession #: | P18627 |
| Applications: | BA |
Simple Plex Human LAG-3 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
Dual inhibitor of LAG3 interaction with both MHCII and FGL1
| Chemical Name: | N-[4-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethoxy]phenyl]-2-furancarboxamide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #1058221 |
| Applications: | IHC, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #874512 |
| Applications: | Flow, IHC, CyTOF-ready |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow |
Biotinylated
| Source: | CHO |
| Accession #: | P18627.5 |
| Applications: | BA |
| Reactivity: | Human, Mouse, Monkey |
| Details: | Mouse IgG1 Monoclonal Clone #11E3 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +1 More |
![Flow Cytometry: LAG-3 Antibody (11E3) - BSA Free [NBP1-97662]](https://resources.bio-techne.com/images/products/LAG-3-Antibody-11E3-Flow-Cytometry-NBP1-97662-img0001.jpg "Flow Cytometry: LAG-3 Antibody (11E3) - BSA Free [NBP1-97662]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
| Source: | NS0 |
| Accession #: | Q61790 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #1009611 |
| Applications: | WB, Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #874528 |
| Applications: | Flow, IHC, CyTOF-ready |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow |
| Applications: | IHC, WB, Flow |
![Flow Cytometry: LAG-3 Antibody Pack [NBP3-11743]](https://resources.bio-techne.com/images/products/LAG-3-Antibody-Pack-Flow-Cytometry-NBP3-11743-img0001.jpg "Flow Cytometry: LAG-3 Antibody Pack [NBP3-11743]")
| Source: | NS0 |
| Accession #: | P18627 |
| Applications: | BA |
| Assay Range: | 93.8 - 6,000 pg/mL |
| Applications: | ELISA |
