Salubrinal

Name: Salubrinal
Brand: Tocris Bioscience
SKU: 2347

Tocris Bioscience, part of Bio-Techne | Catalog # 2347

Citations (90)

COA / SDS

Selective inhibitor of eIF2α dephosphorylation

Key Product Details

Chemical Name:	3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
Purity:	≥99%
Molecular Weight:	479.81 kDa

View Full Technical Details for Salubrinal

Technical Data
Citations

Biological Activity for Salubrinal

Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC₅₀ ~ 15 μM).

Technical Data for Salubrinal

M. Wt	479.81 kDa
Formula	C₂₁H₁₇N₄OSCl₃
Storage	Store at +4°C
Purity	≥99%
CAS Number	405060-95-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Salubrinal

Solubility

Soluble Soluble to 100 mM in DMSO

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Salubrinal

References are publications that support the biological activity of the product.

Sodhi C, Jia H, Yamaguchi Y, Lu P, Good M, Egan C, Ozolek J, Zhu X, Billiar T, Hackam D Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut. J Immunol, 2015;194(10):4931-9. 2015 PMID: 25862813
Shrestha N, Bahnan W, Wiley D, Barber G, Fields K, Schesser K Eukaryotic initiation factor 2 (eIF2) signaling regulates proinflammatory cytokine expression and bacterial invasion. J Biol Chem, 2012;287(34):28738-44. 2012 PMID: 22761422
K Minami, S Liu, Y Liu, A Chen, Q Wan, S Na, BY Li, N Matsuura, M Koizumi, Y Yin, L Gan, A Xu, J Li, H Nakshatri, H Yokota Inhibitory Effects of Dopamine Receptor D1 Agonist on Mammary Tumor and Bone Metastasis Sci Rep, 2017;7(0):45686. 2017 PMID: 28374823
Gu L, Johno H, Nakajima S, Kato H, Takahashi S, Katoh R, Kitamura M Blockade of Smad signaling by 3'-deoxyadenosine: a mechanism for its anti-fibrotic potential. Lab Invest, 2013;93(4):450-61. 2013 PMID: 23439432
Boyce et al. A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science, 2005;307:935 PMID: 15705855
Long et al. Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg.Med.Chem.Lett., 2005;15:3849 PMID: 16002288