SB 203580 hydrochloride

Name: SB 203580 hydrochloride
Brand: Tocris Bioscience
SKU: 1402
Rating: 5 (4 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1402

(4)

Citations (24)

COA / SDS

Selective inhibitor of p38 MAPK; water-soluble

Key Product Details

Description:	Selective inhibitor of p38 MAPK; water-soluble
Chemical Name:	4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H-imidazol-4-yl]pyridine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	413.89

View Full Technical Details for SB 203580 hydrochloride

Technical Data
Citations / Reviews (4)

Biological Activity for SB 203580 hydrochloride

SB 203580 hydrochloride is a water-soluble salt of SB 203580 (Cat. No. 1202). Selective inhibitor of p38 mitogen-activated protein kinase (IC₅₀ values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β and PKBα. Shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.

Technical Data for SB 203580 hydrochloride

M. Wt	413.89
Formula	C₂₁H₁₆FN₃OS.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	869185-85-3
PubChem ID	16760644
InChi Key	WOSGGXINSLMASH-UHFFFAOYSA-N
Smiles	Cl.CS(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 203580 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	10.35	25

Preparing Stock Solutions for SB 203580 hydrochloride

The following data is based on the product molecular weight 413.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.66 mL	48.32 mL	96.64 mL
1.25 mM	1.93 mL	9.66 mL	19.33 mL
2.5 mM	0.97 mL	4.83 mL	9.66 mL
12.5 mM	0.19 mL	0.97 mL	1.93 mL

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References for SB 203580 hydrochloride

References are publications that support the biological activity of the product.

Saklatvala Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue. J.Biol.Chem. 1996 PMID: 8636072
Cuenda SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 1995 PMID: 7750577
Davies Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 2000 PMID: 10998351
Borsch-Haubold Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. J.Biol.Chem. 1998 PMID: 9786874