SB 203580 hydrochloride

Name: SB 203580 hydrochloride
Brand: Tocris Bioscience
SKU: 1402

Tocris Bioscience, part of Bio-Techne | Catalog # 1402

(4)

Citations (24)

COA / SDS

Selective inhibitor of p38 MAPK; water-soluble

Key Product Details

Chemical Name:	4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H-imidazol-4-yl]pyridine hydrochloride
Purity:	≥98%
Molecular Weight:	413.89 kDa

View Full Technical Details for SB 203580 hydrochloride

Technical Data
Citations / Reviews (4)

Biological Activity for SB 203580 hydrochloride

SB 203580 hydrochloride is a water-soluble salt of SB 203580 (Cat. No. 1202). Selective inhibitor of p38 mitogen-activated protein kinase (IC₅₀ values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β and PKBα. Shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.

Technical Data for SB 203580 hydrochloride

M. Wt	413.89 kDa
Formula	C₂₁H₁₆FN₃OS.HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	869185-85-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 203580 hydrochloride

Solubility

Soluble Soluble to 25 mM in water

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References for SB 203580 hydrochloride

References are publications that support the biological activity of the product.

Davies et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J., 2000;351:95 PMID: 10998351
Cuenda et al. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett., 1995;364:229 PMID: 7750577
Borsch-Haubold et al. Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. J.Biol.Chem., 1998;273:28766 PMID: 9786874
Saklatvala et al. Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue. J.Biol.Chem., 1996;271:6586 PMID: 8636072