SB 203580

Name: SB 203580
Brand: Tocris Bioscience
SKU: 1202
Rating: 5 (4 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1202

(4)

Citations (623)

COA / SDS

Selective inhibitor of p38 MAPK

Key Product Details

Description:	Selective inhibitor of p38 MAPK
Chemical Name:	4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine
Purity:	≥98% (HPLC)
Molecular Weight:	377.44

View Full Technical Details for SB 203580

Technical Data
Citations / Reviews (4)

Biological Activity for SB 203580

SB 203580 is a selective inhibitor of p38 MAPK (IC₅₀ values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. Shown to inhibit IL-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. SB 203580 is an essential component of medium for maintaining stem cells in naive pluripotent state and can be used to promote expansion of HSCs ex vivo.

Water-soluble Salt also available.

Compound Libraries for SB 203580

SB 203580 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for SB 203580

M. Wt	377.44
Formula	C₂₁H₁₆FN₃OS
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	152121-47-6
PubChem ID	176155
InChi Key	CDMGBJANTYXAIV-UHFFFAOYSA-N
Smiles	CS(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 203580

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.44	25

Preparing Stock Solutions for SB 203580

The following data is based on the product molecular weight 377.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.60 mL	52.99 mL	105.98 mL
1.25 mM	2.12 mL	10.60 mL	21.20 mL
2.5 mM	1.06 mL	5.30 mL	10.60 mL
12.5 mM	0.21 mL	1.06 mL	2.12 mL

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References for SB 203580

References are publications that support the biological activity of the product.

Jiang Effects of signaling pathway inhibitors on hematopoietic stem cells. Mol.Med.Rep. 2021 PMID: 33179097
Gafni Derivation of novel human ground state naive pluripotent stem cells. Nature 2013 PMID: 24172903
Sato Inhibitors of p38 mitogen-activated protein kinase enhance proliferation of mouse neural stem cells. J.Neurosci.Res. 2008 PMID: 18338804
Saklatvala Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue. J.Biol.Chem. 1996 PMID: 8636072
Davies Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 2000 PMID: 10998351
Borsch-Haubold Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. J.Biol.Chem. 1998 PMID: 9786874