SB 332235

Name: SB 332235
Brand: Tocris Bioscience
SKU: 5671

Tocris Bioscience, part of Bio-Techne | Catalog # 5671

Citations (4)

COA / SDS

Potent CXCR2 antagonist

Key Product Details

Description:	Potent CXCR2 antagonist
Chemical Name:	6-Chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxybenzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	410.66

View Full Technical Details for SB 332235

Technical Data
Citations

Biological Activity for SB 332235

SB 332235 is a potent CXCR2 antagonist (IC₅₀ = 7.7 nM). Exhibits 285-fold selectivity for CXCR2 over CXCR1. Reduces leukocyte numbers in synovial fluid in acute and chronic rabbit arthritis models. Also reduces synovial fluid eicosanoid and cytokine levels in a rabbit chronic arthritis model. Inhibits proliferation of AML cell lines in vitro.

Compound Libraries for SB 332235

SB 332235 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SB 332235

M. Wt	410.66
Formula	C₁₃H₁₀Cl₃N₃O₄S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	276702-15-9
PubChem ID	9887803
InChi Key	WTLRWOHEKQGKDS-UHFFFAOYSA-N
Smiles	ClC1=C(S(=O)(N)=O)C(O)=C(NC(NC2=C(Cl)C(Cl)=CC=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 332235

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.07	100

Preparing Stock Solutions for SB 332235

The following data is based on the product molecular weight 410.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.18 mL	24.35 mL
5 mM	0.49 mL	2.44 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for SB 332235

References are publications that support the biological activity of the product.

Schinke IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells. Blood 2015 PMID: 25810490
Podolin A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J.Immunol. 2002 PMID: 12444152