SB 366791

Name: SB 366791
Brand: Tocris Bioscience
SKU: 1615

Tocris Bioscience, part of Bio-Techne | Catalog # 1615

Citations (85)

COA / SDS

Potent and selective TRPV1 competitive antagonist

Key Product Details

Description:	Potent and selective TRPV1 competitive antagonist
Chemical Name:	4'-Chloro-3-methoxycinnamanilide
Purity:	≥99% (HPLC)
Molecular Weight:	287.75

View Full Technical Details for SB 366791

Technical Data
Citations

Biological Activity for SB 366791

SB 366791 is a potent, selective and competitive vanilloid TRPV1 receptor antagonist (pA₂ = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB₁ and CB₂ receptors, voltage-gated Ca²⁺ channels and the hyperpolarization-activated current (I_h).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for SB 366791

SB 366791 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SB 366791

M. Wt	287.75
Formula	C₁₆H₁₄ClNO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	472981-92-3
PubChem ID	667594
InChi Key	RYAMDQKWNKKFHD-JXMROGBWSA-N
Smiles	COC1=CC=CC(NC(=O)\C=C\C2=CC=C(Cl)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 366791

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	2.88	10
	DMSO	28.77	100

Preparing Stock Solutions for SB 366791

The following data is based on the product molecular weight 287.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.48 mL	17.38 mL	34.75 mL
5 mM	0.70 mL	3.48 mL	6.95 mL
10 mM	0.35 mL	1.74 mL	3.48 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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References for SB 366791

References are publications that support the biological activity of the product.

Gavva Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Mol.Pharmacol. 2005 PMID: 16135784
Gunthorpe Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology 2004 PMID: 14654105
Fowler Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. Biochem.Pharmacol. 2003 PMID: 12948856