SDZ 220-581

Name: SDZ 220-581
Brand: Tocris Bioscience
SKU: 1250

Tocris Bioscience, part of Bio-Techne | Catalog # 1250

Citations (52)

COA / SDS

Competitive NMDA antagonist

Key Product Details

Description:	Competitive NMDA antagonist
Chemical Name:	(S)-α-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	369.74

View Full Technical Details for SDZ 220-581

Technical Data
Citations

Biological Activity for SDZ 220-581

SDZ 220-581 is a competitive NMDA receptor antagonist (pK_i = 7.7). Centrally active following oral administration (ED₅₀ < 3.2 mg/kg for protection against MES-induced seizures).

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data for SDZ 220-581

M. Wt	369.74
Formula	C₁₆H₁₇ClNO₅P
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	174575-17-8
PubChem ID	128019
InChi Key	VBRJFXSFCYEZMQ-HNNXBMFYSA-N
Smiles	OC([C@@H](N)CC1=CC(C2=CC=CC=C2Cl)=CC(CP(O)(O)=O)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SDZ 220-581

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	9.24	25 with gentle warming
	1.1eq. NaOH	36.97	100

Preparing Stock Solutions for SDZ 220-581

The following data is based on the product molecular weight 369.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.70 mL	13.52 mL	27.05 mL
5 mM	0.54 mL	2.70 mL	5.41 mL
10 mM	0.27 mL	1.35 mL	2.70 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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Reconstitution Calculator

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References for SDZ 220-581

References are publications that support the biological activity of the product.

Urwyler Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-MthD.-aspartate receptor antagonists - I. Pharmacological characterization in vitro. Neuropharmacology 1996 PMID: 8887974
Urwyler Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-MthD.-aspartate receptor antagonists - II. Pharmacological characterization in vivo. Neuropharmacology 1996 PMID: 8887975
Bakshi Disruption of prepulse inhibition and increases in locomotor activity by competitive N-MthD.-aspartate receptor antagonists in rats. J.Pharmacol.Exp.Ther. 1999 PMID: 9918570