SJ 6986

Name: SJ 6986
Brand: Tocris Bioscience
SKU: 7720

Tocris Bioscience, part of Bio-Techne | Catalog # 7720

COA / SDS

Molecular glue; induces degradation of GSPT1/2

Key Product Details

Description:	Molecular glue; induces degradation of GSPT1/2
Chemical Name:	N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	497.4

View Full Technical Details for SJ 6986

Technical Data
Citations

Biological Activity for SJ 6986

SJ 6986 is a potent and selective GSPT1/2 molecular glue Degrader (DC₅₀ = 2.1 nM). The Degrader exhibits antiproliferative effects in human medulloblastoma and leukemia cell lines. (EC₅₀ values are 0.4 nM, 1.5 nM, 336 nM, 726 nM and 3583 nM in MHH-CALL-4, MV4-11, MB004, MB002 and HD-MB03 cell lines, respectively). In vivo, SJ 6986 is stable in mouse (t_1/2 = 4.7 h). This product is orally bioavailable.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Technical Data for SJ 6986

M. Wt	497.4
Formula	C₂₀H₁₄F₃N₃O₇S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2765625-93-0
PubChem ID	155925914
InChi Key	RKAFYSIKAVFVPS-UHFFFAOYSA-N
Smiles	O=S(C1=CC=CC=C1OC(F)(F)F)(NC2=CC(C(N3C4C(NC(CC4)=O)=O)=O)=C(C=C2)C3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SJ 6986

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.74	100

Preparing Stock Solutions for SJ 6986

The following data is based on the product molecular weight 497.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.01 mL	10.05 mL	20.10 mL
5 mM	0.40 mL	2.01 mL	4.02 mL
10 mM	0.20 mL	1.01 mL	2.01 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for SJ 6986

References are publications that support the biological activity of the product.

Nishiguchi Identification of potent, selective, and orally bioavailable small- molecule GSPT1/2 degraders from a focused library of cereblon modulators. J.Med.Chem. 2021 PMID: 34042448