SJFα

Name: SJFα
Brand: Tocris Bioscience
SKU: 7268

Tocris Bioscience, part of Bio-Techne | Catalog # 7268

COA / SDS

Potent and selective p38α PROTAC®

Key Product Details

Description:	Potent and selective p38α PROTAC^®
Alternative Names:	SJFa PROTAC,SJFalpha PROTAC,SJFα PROTAC
Chemical Name:	N-(3-Fluoro-4-((7-(4-(4-(2-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)butoxy)butoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1120.28

View Full Technical Details for SJFα

Technical Data
Citations

Biological Activity for SJFα

SJFα is a potent and selective p38α PROTAC^® Degrader (DC₅₀ = 7.16 nM; D_max = 97.4%). SJFα comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Displays significantly lower potency degradation at p38δ (DC₅₀ = 299 nM). Exhibits no significant degradation of p38β, p38γ or related MAPKs, ERK1/2, or JNK1/2.

p38γ antibodies validated for Simple Western™ (automated Western) instruments also available: Catalog # AF1347 and MAB1347.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for SJFα

M. Wt	1120.28
Formula	C₅₉H₆₇F₂N₇O₁₁S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2254609-27-1
PubChem ID	137628677
InChi Key	GXDYWQXTEYENEU-WFYKIECOSA-N
Smiles	COC1=CC2=C(N=CC=C2OC3=C(C=C(C=C3)NC(C4(C(NC5=CC=C(C=C5)F)=O)CC4)=O)F)C=C1OCCCCOCCCCOCC(N[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SJFα

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	112.03	100

Preparing Stock Solutions for SJFα

The following data is based on the product molecular weight 1120.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.89 mL	4.46 mL	8.93 mL
5 mM	0.18 mL	0.89 mL	1.79 mL
10 mM	0.09 mL	0.45 mL	0.89 mL
50 mM	0.02 mL	0.09 mL	0.18 mL

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References for SJFα

References are publications that support the biological activity of the product.

Smith Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat. Commun. 2019 PMID: 30631068