SR 16832

Name: SR 16832
Brand: Tocris Bioscience
SKU: 6383

Tocris Bioscience, part of Bio-Techne | Catalog # 6383

Citations (2)

COA / SDS

Dual site PPARγ inhibitor

Key Product Details

Description:	Dual site PPARγ inhibitor
Chemical Name:	2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	357.75

View Full Technical Details for SR 16832

Technical Data
Citations

Biological Activity for SR 16832

SR 16832 is a dual site PPARγ inhibitor. Acts at orthosteric and allosteric sites in the ligand binding domain. Inhibits binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonists GW 9662 (Cat. No. 1508) and T 0070907 (Cat. No. 2301).

Compound Libraries for SR 16832

SR 16832 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 16832

M. Wt	357.75
Formula	C₁₇H₁₂ClN₃O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	2088135-12-8
PubChem ID	134160241
InChi Key	CVTZAGCRUDYUGB-UHFFFAOYSA-N
Smiles	COC1=CC2=C(N=CC=C2NC(C3=CC([N+]([O-])=O)=CC=C3Cl)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 16832

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.89	50

Preparing Stock Solutions for SR 16832

The following data is based on the product molecular weight 357.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.59 mL	27.95 mL	55.90 mL
2.5 mM	1.12 mL	5.59 mL	11.18 mL
5 mM	0.56 mL	2.80 mL	5.59 mL
25 mM	0.11 mL	0.56 mL	1.12 mL

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Reconstitution Calculator

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References for SR 16832

References are publications that support the biological activity of the product.

Brust Modification of the othosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor. ACS Chem.Biol. 2017 PMID: 28165718