T 0070907

Name: T 0070907
Brand: Tocris Bioscience
SKU: 2301
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2301

(2)

Citations (52)

COA / SDS

Highly potent and selective covalent PPARγ antagonist

Key Product Details

Chemical Name:	2-Chloro-5-nitro-N-4-pyridinylbenzamide
Purity:	≥99%

View Full Technical Details for T 0070907

Technical Data
Citations / Reviews (2)

Biological Activity for T 0070907

T 0070907 is a potent and selective irreversible PPARγ antagonist (IC₅₀ = 1 nM). Displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. Blocks transcriptional activity of PPARγ in vitro and inhibits Rosiglitazone-induced adipogenesis.

Technical Data for T 0070907

Formula	C₁₂H₈N₃O₃Cl
Storage	Store at RT
Purity	≥99%
CAS Number	313516-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for T 0070907

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl

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References for T 0070907

References are publications that support the biological activity of the product.

Yukihiro Saito, Kazufumi Nakamura, Daiji Miura, Kei Yunoki, Toru Miyoshi, Masashi Yoshida, Norifumi Kawakita, Tomonari Kimura, Megumi Kondo, Toshihiro Sarashina, Satoshi Akagi, Atsuyuki Watanabe, Nobuhiro Nishii, Hiroshi Morita, Hiroshi Ito Suppression of Wnt Signaling and Osteogenic Changes in Vascular Smooth Muscle Cells by Eicosapentaenoic Acid. Nutrients, 2017;0(0):2072-6643. 2017 PMID: 28796175
Lee et al. T0070907, a selective ligand for peroxisome proliferator-activated receptor γ, functions as an antagonist of biochemical and cellular activities. J.Biol.Chem., 2002;277:19649 PMID: 11877444
Rockwell and Kaminski A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. J.Pharmacol.Exp.Ther., 2004;311:683 PMID: 15284281
Schaefer et al. Peroxisome proliferator-activated receptor γ inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells. Cancer Res., 2005;65:2251 PMID: 15781638

T 0070907

Tocris Bioscience, part of Bio-Techne | Catalog # 2301

Key Product Details

Biological Activity for T 0070907

Technical Data for T 0070907

Solubility for T 0070907

Dilution Calculator

Reconstitution Calculator

References for T 0070907

Product Documents for T 0070907

COA

Certificate of Analysis

SDS

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