Sulfasalazine

Name: Sulfasalazine
Brand: Tocris Bioscience
SKU: 4935

Tocris Bioscience, part of Bio-Techne | Catalog # 4935

Citations (9)

COA / SDS

Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1

Key Product Details

Description:	Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1
Chemical Name:	5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid
Purity:	≥97% (HPLC)
Molecular Weight:	398.39

View Full Technical Details for Sulfasalazine

Technical Data
Citations

Biological Activity for Sulfasalazine

Sulfasalazine is an inhibitor of NF-κB activation. Inhibits in vitro growth of the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, and induces apoptosis in glioblastoma cell lines. Also inhibits the cystine-glutamate antiporter, system X_c (SXC). Inhibitor of folate transporter 1 (SLC19A1); inhibits cellular uptake of Methotrexate (Cat. No. 1230) and cyclic dinucleotides, including 2',3'-cGAMP (Cat.No. 5945). Anti-inflammatory. Induces ferroptosis.

Compound Libraries for Sulfasalazine

Sulfasalazine is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Sulfasalazine

M. Wt	398.39
Formula	C₁₈H₁₄N₄O₅S
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	599-79-1
PubChem ID	5359476
InChi Key	OQANPHBRHBJGNZ-BKUYFWCQSA-N
Smiles	OC1=CC=C(/N=N/C2=CC=C(S(NC3=NC=CC=C3)(=O)=O)C=C2)C=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sulfasalazine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.84	100

Preparing Stock Solutions for Sulfasalazine

The following data is based on the product molecular weight 398.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.55 mL	25.10 mL
5 mM	0.50 mL	2.51 mL	5.02 mL
10 mM	0.25 mL	1.26 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for Sulfasalazine

References are publications that support the biological activity of the product.

Xie Ferroptosis: process and function. Cell Death Differ. 2016 PMID: 26794443
Luteijn SLC19A1 transports immunoreactive cyclic dinucleotides. Nature 2019 PMID: 31511694
Jansen Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis. Arthritis Rheum. 2004 PMID: 15248210
Sontheimer and Bridges Sulfasalazine for brain cancer fits. Expert Opin.Invest.Drugs 2012 PMID: 22404218
Lo Potential use fo the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer. Curr.Oncol. 2010 PMID: 20567622
Robe In vitro and in vivo activity of the nuclear factor-κB inhbitor sulfasal. in human glioblastomas. Clin.Cancer Res. 2004 PMID: 15328202

Product Documents for Sulfasalazine

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Sulfasalazine (Salicylazosulfapyridine), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov